2'-Adenylic acid, N-benzoyl-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 2-cyanoethyl ethyl ester, 5'-(2-cyanoethyl ethyl phosphate)

Base Information

• Chemical Name: 2'-Adenylic acid, N-benzoyl-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 2-cyanoethyl ethyl ester, 5'-(2-cyanoethyl ethyl phosphate)
• CAS No.: 140210-72-6
• Molecular Formula: C33H47N7O11P2Si
• Mol file: 140210-72-6.mol

Synonyms:

Chemical Property of 2'-Adenylic acid, N-benzoyl-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 2-cyanoethyl ethyl ester, 5'-(2-cyanoethyl ethyl phosphate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-Adenylic acid, N-benzoyl-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 2-cyanoethyl ethyl ester, 5'-(2-cyanoethyl ethyl phosphate)

There total 1 articles about 2'-Adenylic acid, N-benzoyl-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 2-cyanoethyl ethyl ester, 5'-(2-cyanoethyl ethyl phosphate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-Cyanoethoxy)-(ethoxy)-(N,N-diisopropylamino)phosphine (140210-65-7) + N-{9-[(2R,3R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide (69504-08-1) → 6-N-Benzoyl-3'-O-t-butyldimethylsilyladenosine 2',5'-bis(O-(2-cyanoethyl)-O-ethylphosphate) (140210-72-6)

Guidance literature:

With pyridine; 1H-tetrazole; water; iodine; Yield given. Multistep reaction; 1) DMF, MeCN, r.t., 40 min, 2) THF, 15 min;

DOI:10.1016/S0040-4020(01)88130-8

Reference yield:

6-N-Benzoyl-3'-O-t-butyldimethylsilyladenosine 2',5'-bis(O-(2-cyanoethyl)-O-ethylphosphate) (140210-72-6) → Sodium adenosine 2',5'-bis(ethylphosphate) (140210-73-7)

Guidance literature:

With ammonium hydroxide; tetrabutyl ammonium fluoride; Yield given. Multistep reaction; 1) dioxane, r.t., 24 h, 2) THF, r.t., 20 h;

DOI:10.1016/S0040-4020(01)88130-8

upstream raw materials:

(2-Cyanoethoxy)-(ethoxy)-(N,N-diisopropylamino)phosphine

N-{9-[(2R,3R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

Downstream raw materials:

Sodium adenosine 2',5'-bis(ethylphosphate)