(11BR)-2,6-BIS(DIPHENYLPHOSPHINO)-N,N-DIMETHYLDINAPHTHO(2,1-D:1',2'-F)-1,3,2-DIOXAPHOSPHEPIN-4-AMINE, KANATA PURITY

Base Information

• Chemical Name: (11BR)-2,6-BIS(DIPHENYLPHOSPHINO)-N,N-DIMETHYLDINAPHTHO(2,1-D:1',2'-F)-1,3,2-DIOXAPHOSPHEPIN-4-AMINE, KANATA PURITY
• CAS No.: 913617-04-6
• Molecular Formula: C₄₆H₃₆NO₂P₃
• Molecular Weight: 727.719
• Mol file: 913617-04-6.mol

Synonyms:

Chemical Property of (11BR)-2,6-BIS(DIPHENYLPHOSPHINO)-N,N-DIMETHYLDINAPHTHO(2,1-D:1',2'-F)-1,3,2-DIOXAPHOSPHEPIN-4-AMINE, KANATA PURITY

Chemical Property:

• Melting Point: 245-249?°C
• PKA: 0.85±0.20(Predicted)
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(11bR)-2,6-Bis(diphenylphosphino)-N,N-dimethyldinaphtho[2,1-d:1′,2′-f]-1,3,2-dioxaphosphepin-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (11bR)-2,6-Bis(diphenylphosphino)-N,N-dimethyldinaphtho[2,1-d:1′,2′-f]-1,3,2-dioxaphosphepin-4-amine is a phosphine-phosphoramidite ligand, which can be used in: The stereoselective preparation of aminoesters via rhodium-catalyzed enantioselective hydrogenation of dehydroaminoesters. The Rh-catalyzed asymmetric hydrogenation of N-(α-arylvinyl) acetamides.

Technology Process of (11BR)-2,6-BIS(DIPHENYLPHOSPHINO)-N,N-DIMETHYLDINAPHTHO(2,1-D:1',2'-F)-1,3,2-DIOXAPHOSPHEPIN-4-AMINE, KANATA PURITY

There total 4 articles about (11BR)-2,6-BIS(DIPHENYLPHOSPHINO)-N,N-DIMETHYLDINAPHTHO(2,1-D:1',2'-F)-1,3,2-DIOXAPHOSPHEPIN-4-AMINE, KANATA PURITY which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(R)-3,3'-bis(diphenylphosphino)-[1,1'-binaphthalene]-2,2'-diol + Hexamethylphosphorous triamide (1608-26-0) → (R)-O,O'-(3,3'-bis(diphenylphosphino)-1,1'-binaphthyl-2,2'-diyl)-N,N'-dimethylphosphorous triamide (913617-04-6)

Guidance literature:

In toluene; at 110 ℃;

DOI:10.1002/anie.200601501

Reference yield:

(R)-2,2'-bis(methoxymethoxy)-3,3'-bis(diphenylphosphino)-1,1'-binaphthyl → (R)-O,O'-(3,3'-bis(diphenylphosphino)-1,1'-binaphthyl-2,2'-diyl)-N,N'-dimethylphosphorous triamide (913617-04-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / HCl / methanol; H₂O / 1 h / 60 °C

2: 88 percent / toluene / 110 °C

With hydrogenchloride; In methanol; water; toluene;

DOI:10.1002/anie.200601501

Reference yield:

(R)-1,1'-Bi-2-naphthol (18531-94-7) → (R)-O,O'-(3,3'-bis(diphenylphosphino)-1,1'-binaphthyl-2,2'-diyl)-N,N'-dimethylphosphorous triamide (913617-04-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 98 percent / NaH / tetrahydrofuran / 0 °C

2.1: n-BuLi / diethyl ether; hexane; tetrahydrofuran / 4 h / 20 °C

2.2: 70 percent / hexane; tetrahydrofuran; diethyl ether / 1 h / cooling

3.1: 79 percent / HCl / methanol; H₂O / 1 h / 60 °C

4.1: 88 percent / toluene / 110 °C

With hydrogenchloride; n-butyllithium; sodium hydride; In tetrahydrofuran; methanol; diethyl ether; hexane; water; toluene;

DOI:10.1002/anie.200601501

upstream raw materials:

Hexamethylphosphorous triamide

(R)-1,1'-Bi-2-naphthol