MK8745

Base Information

• Chemical Name: MK8745
• CAS No.: 885325-71-3
• Molecular Formula: C₂₀H₁₉ClFN₅OS
• Molecular Weight: 431.921
• Mol file: 885325-71-3.mol

Synonyms:

Chemical Property of MK8745

Chemical Property:

• Melting Point: 177-179°C
• Boiling Point: 605.5±65.0 °C(Predicted)
• PKA: 5.20±0.10(Predicted)
• Density: 1.430±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

97% ^*data from raw suppliers

MK-8745 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: MK-8745 is a potent and selective Aurora A kinase inhibitor that induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages.

Technology Process of MK8745

There total 1 articles about MK8745 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(chloromethyl)-N-thiazol-2-ylpyridin-2-amine (885325-74-6) + 1-(3-chloro-2-fluorobenzoyl)piperazine (885325-75-7) → MK-8745 (885325-71-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 90 ℃; for 2h;

upstream raw materials:

6-(chloromethyl)-N-thiazol-2-ylpyridin-2-amine

1-(3-chloro-2-fluorobenzoyl)piperazine