3'-CYANO-2-PHENYLACETOPHENONE

Base Information

• Chemical Name: 3'-CYANO-2-PHENYLACETOPHENONE
• CAS No.: 758710-68-8
• Molecular Formula: C₁₅H₁₁NO
• Molecular Weight: 221.258
• Mol file: 758710-68-8.mol

Synonyms:

Chemical Property of 3'-CYANO-2-PHENYLACETOPHENONE

Chemical Property:

• Vapor Pressure: 2.88E-06mmHg at 25°C
• Boiling Point: 389.3±25.0 °C(Predicted)
• Density: 1.16±0.1 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

3'-Cyano-2-phenylacetophenone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3'-CYANO-2-PHENYLACETOPHENONE

There total 7 articles about 3'-CYANO-2-PHENYLACETOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3-[1-(tert-butyldimethylsilyloxy)-1-cyano-2-phenylethyl]benzonitrile → 3-(2-phenylacetyl)benzonitrile (758710-68-8)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

DOI:10.1055/s-0036-1590887

Reference yield: 80.7%

zinc(II) cyanide (557-21-1) + 1-(3-bromophenyl)-2-phenylethan-1-one (40396-53-0) → 3-(2-phenylacetyl)benzonitrile (758710-68-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 80 ℃; for 20h; Inert atmosphere;

Reference yield: 72.0%

3-(cyano((trimethylsilyl)oxy)methyl)benzonitrile (1135344-52-3) + benzyl bromide (100-39-0) → 3-(2-phenylacetyl)benzonitrile (758710-68-8)

Guidance literature:

3-(cyano((trimethylsilyl)oxy)methyl)benzonitrile; benzyl bromide; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 20 ℃; for 24h;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.5h;

DOI:10.1021/acs.jmedchem.9b00445

upstream raw materials:

benzyl bromide

3-cyanobenzoyl chloride

zinc(II) cyanide

1-(3-bromophenyl)-2-phenylethan-1-one

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