1H-Thieno[3,4-d]iMidazole-4-pentanaMide, N-[2-(4-aMinophenyl)ethyl]hexahydro-2-oxo-, (3aS,4S,6aR)-

Base Information

• Chemical Name: 1H-Thieno[3,4-d]iMidazole-4-pentanaMide, N-[2-(4-aMinophenyl)ethyl]hexahydro-2-oxo-, (3aS,4S,6aR)-
• CAS No.: 769933-15-5
• Molecular Formula: C₁₈H₂₆N₄O₂S
• Molecular Weight: 362.496
• Mol file: 769933-15-5.mol

Synonyms:

Chemical Property of 1H-Thieno[3,4-d]iMidazole-4-pentanaMide, N-[2-(4-aMinophenyl)ethyl]hexahydro-2-oxo-, (3aS,4S,6aR)-

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Biotin-aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Thieno[3,4-d]iMidazole-4-pentanaMide, N-[2-(4-aMinophenyl)ethyl]hexahydro-2-oxo-, (3aS,4S,6aR)-

There total 3 articles about 1H-Thieno[3,4-d]iMidazole-4-pentanaMide, N-[2-(4-aMinophenyl)ethyl]hexahydro-2-oxo-, (3aS,4S,6aR)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-Aminophenethylamine (13472-00-9) + biotin N-hydroxysuccinimide ester (85718-04-3) → C18H26N4O2S (769933-15-5)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

Reference yield:

p-Aminophenethylamine (13472-00-9) + biotin N-Hydroxysuccinimide ester (35013-72-0) → N-(4-aminophenethyl)biotinamide (769933-15-5)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1002/anie.201905949

Reference yield:

biotin (58-85-5,22879-79-4) → N-(4-aminophenethyl)biotinamide (769933-15-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

2: triethylamine / N,N-dimethyl-formamide / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1002/anie.201905949

upstream raw materials:

p-Aminophenethylamine

biotin N-hydroxysuccinimide ester

biotin N-Hydroxysuccinimide ester

biotin

Refernces

• 1、 -. "Anti-inflammatory conformal barriers for cell transplantation". Figure 13. . Retrieved 2008/06/13.