2-ethoxy-5H-pyrido[3,2-b]indole

Base Information

• Chemical Name: 2-ethoxy-5H-pyrido[3,2-b]indole
• CAS No.: 1300728-17-9
• Molecular Formula: C₁₃H₁₂N₂O
• Molecular Weight: 212.251
• Mol file: 1300728-17-9.mol

Synonyms:

Chemical Property of 2-ethoxy-5H-pyrido[3,2-b]indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-ethoxy-5H-pyrido[3,2-b]indole

There total 2 articles about 2-ethoxy-5H-pyrido[3,2-b]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(2-chlorophenyl)-6-ethoxypyridin-3-amine (1300728-00-0) → 2-ethoxy-5H-pyrido[3,2-b]indole (1300728-17-9) + 3-Ethoxy-beta-carboline (91985-81-8)

Guidance literature:

With palladium diacetate; potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate; In N,N-dimethyl acetamide; at 120 ℃; for 16h; regioselective reaction; Inert atmosphere; Sealed vessel;

DOI:10.1021/jo200425m

Reference yield:

5-bromo-2-ethoxypyridine (55849-30-4) + o-chloroaniline (95-51-2) → 2-ethoxy-5H-pyrido[3,2-b]indole (1300728-17-9) + 3-Ethoxy-beta-carboline (91985-81-8)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium diacetate; caesium carbonate; XPhos / toluene / 15 h / 100 °C / Inert atmosphere

2: palladium diacetate; potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate / N,N-dimethyl acetamide / 16 h / 120 °C / Inert atmosphere; Sealed vessel

With palladium diacetate; potassium carbonate; caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; XPhos; In N,N-dimethyl acetamide; toluene; 1: Buchwald-Hartwig amination / 2: Heck reaction;

DOI:10.1021/jo200425m

upstream raw materials:

5-bromo-2-ethoxypyridine

o-chloroaniline

N-(2-chlorophenyl)-6-ethoxypyridin-3-amine