55849-30-4

Basic information

• Product Name: 5-Bromo-2-ethoxypyridine
• Synonyms: Bromo-2-ethoxypyridine;5-Bromo-2-ethoxypyri;5-Bromo-2-ethoxypyridine 99%;5-BroMo-2-ethoxypyridine, 97+%;2-ETHOXY-5-BROMOPYRIDINE;5-BROMO-2-ETHOXYPYRIDINE;PYRIDINE, 5-BROMO-2-ETHOXY-;2-Ethoxypyridine-5-bromopyridine
• CAS NO: 55849-30-4
• Molecular Formula: C₇H₈BrNO
• Molecular Weight: 202.05
• Product Categories: Heterocycle-Pyridine series;alkyl bromide;blocks;Bromides;Pyridines;Pyridine;pyridine derivative;Pyridine Series;Pyridines, Pyrimidines, Purines and Pteredines;Halides;C7 and C8Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks
• Mol File: 55849-30-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 32-36 °C(lit.)
• Boiling Point: 107°C/33mmHg(lit.)
• Flash Point: 218 °F
• Appearance: Off-white to pale yellow/Solid
• Density: 1.449 g/cm³
• Vapor Pressure: 0.207mmHg at 25°C
• Refractive Index: 1.534
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: soluble in Methanol
• PKA: 1.68±0.22(Predicted)
• CAS DataBase Reference: 5-Bromo-2-ethoxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-2-ethoxypyridine(55849-30-4)
• EPA Substance Registry System: 5-Bromo-2-ethoxypyridine(55849-30-4)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-37/38-41
• Safety Statements: 26-36/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 55849-30-4(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow Cryst

InChI:InChI=1/C7H8BrNO/c1-2-10-7-4-3-6(8)5-9-7/h3-5H,2H2,1H3

Upstream product

• 14529-53-4 2-ethoxypyridine 
• 39856-50-3 5-bromo2-nitropyridine 
• 141-52-6 sodium ethanolate 
• 624-28-2 2,5-dibromopyridine 
• 1072-97-5 5-bromo-2-pyridylamine 
• 64-17-5 ethanol 
• 1493-13-6 trifluorormethanesulfonic acid 
• 2678-54-8 ketene diethyl acetal 
• 114078-88-5 5-bromo-1,2,3-triazine 

Downstream Products

• 1228652-24-1 4-(6-ethoxy-pyridin-3-yl)-4-hydroxy-cyclohexanone 
• 1290546-26-7 N-(2-((R)-1-(trans-4-hydroxy-4-(6-ethoxypyridin-3-yl)cyclohexyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide 
• 97455-61-3 6-ethoxy-3-pyridinecarboxaldehyde 
• 1300640-30-5 2-(ethyloxy)-5-(4-{[1-(4-{[(5-methylpyridin-2-yl)methyl]oxy}phenyl)hydrazino]methyl}phenyl)pyridine 
• 1300640-24-7 5-[4-(bromomethyl)phenyl]-2-(ethyloxy)pyridine hydrobromide 
• 1300640-23-6 5-[4-(bromomethyl)phenyl]-2-(ethyloxy)pyridine 
• 1196070-26-4 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid sodium salt 
• 1196965-16-8 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxy-pyridin-3-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid ethyl ester 
• 936350-00-4 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxy-pyridin-3-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid 
• 1300640-22-5 5-[4-(hydroxymethyl)phenyl]-2-(ethyloxy)pyridine 
• 1300728-00-0 N-(2-chlorophenyl)-6-ethoxypyridin-3-amine 
• 1300728-17-9 2-ethoxy-5H-pyrido[3,2-b]indole 
• 91985-81-8 3-Ethoxy-beta-carboline 
• 14529-53-4 2-ethoxypyridine 

Relevant articles and documents

Novel synthesis method for ortho-alkane superseded pyridine

The invention relates to a novel synthesis method for ortho-alkane superseded pyridine. According to the method, ortho halogenated pyridine serves as raw materials, the ortho halogenated pyridine and corresponding alcohol react to obtain the ortho-alkane superseded pyridine under the action of sodium hydroxide. The reaction has universality for the ortho halogenated pyridine, and the method is simple and practical. Influence of consumption of the sodium hydroxide on mono-substitution and di-substitution in the reaction is inspected, alkoxy mono-substitution products and alkoxy di-substitution production are acquired, and a novel simply-operated, economical and favorable process for synthesis ortho-alkane superseded pyridine is provided.

PYRROLIDINONE DERIVATIVES AS GPR119 MODULATORS FOR THE TREATMENT OF DIABETES, OBESITY, DYSLIPIDEMIA AND RELATED DISORDERS

The present invention relates to pyrrolidinone derivatives of formula (I). The pyrrolidinone derivatives of formula (I) are GPR119 modulators and useful for the prevention and/or treatment of diabetes, obesity, dyslipidemia and related disorders. The invention furthermore relates to the use of pyrrolidinone derivatives as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.

PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS

Provided are compounds according to Formula (I), or stereoisomer, prodrug, polymorph, or pharmaceutically acceptable salt forms thereof, wherein X, Y, R1, R6 , R7, and R8 are as defined, which compounds are effective inhibitors of PI3-kinase and/or other medically and clinically relevant kinases. Also provided are pharmaceutical compositions and methods of using the compounds and compositions as PB -kinase and kinase inhibitors. More particularly, the compounds of the invention provide treatments and therapeutics for human diseases regulated by, or associated with, the activity of, PI3-kinases and/or protein kinases, or mutant or variant forms thereof.