Ethyl (R)-3-Pyrrolidinecarboxylate Hydrochloride

Base Information

• Chemical Name: Ethyl (R)-3-Pyrrolidinecarboxylate Hydrochloride
• CAS No.: 1807350-90-8
• Molecular Formula: C₇H₁₃NO₂*ClH
• Molecular Weight: 179.647
• European Community (EC) Number: 862-618-4
• Mol file: 1807350-90-8.mol

Synonyms:1807350-90-8;Ethyl (R)-3-Pyrrolidinecarboxylate Hydrochloride;Ethyl (r)-3-pyrrolidinecarboxylate, HCl;(R)-ETHYL PYRROLIDINE-3-CARBOXYLATE HCL;(R)-ethyl pyrrolidine-3-carboxylate hydrochloride;ethyl (3R)-pyrrolidine-3-carboxylate;hydrochloride;MFCD18071037;D-beta-Proline ethyl ester hydrochloride;Ethyl (R)-pyrrolidine-3-carboxylate hydrochloride;(R)-(-)-Pyrrolidine-3-carboxylic acid ethyl ester hydrochloride;AKOS008901140;Ethyl(r)-3-pyrrolidinecarboxylate,HCl;AS-43415;CS-0187945;Ethyl(R)-3-PyrrolidinecarboxylateHydrochloride;EN300-7363583;Ethyl (R)-pyrrolidine-3-carboxylate hydrochloride, 95%;ETHYL (3R)-PYRROLIDINE-3-CARBOXYLATE HYDROCHLORIDE

Chemical Property of Ethyl (R)-3-Pyrrolidinecarboxylate Hydrochloride

Chemical Property:

• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 179.0713064
• Heavy Atom Count: 11
• Complexity: 125

Purity/Quality:

99%, ^*data from raw suppliers

Ethyl(R)-3-PyrrolidinecarboxylateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC(=O)C1CCNC1.Cl
• Isomeric SMILES: CCOC(=O)[C@@H]1CCNC1.Cl
• Uses: Ethyl (r)-3-Pyrrolidinecarboxylate Hydrochloride is used as a reactant in the preparation of pyrazolone derivatives as TIP48/TIP49-complex ATPase inhibitors.

Technology Process of Ethyl (R)-3-Pyrrolidinecarboxylate Hydrochloride

There total 4 articles about Ethyl (R)-3-Pyrrolidinecarboxylate Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-t-butyloxycarbonylpyrrole-3-carboxylic acid ethyl ester (170844-49-2,1421256-03-2) → ethyl pyrrolidine-3-carboxylate hydrochloride (80028-44-0,1807350-90-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 3h;

Reference yield:

1-benzyl-3-(ethoxycarbonyl)-5-pyrrolidinone (5733-87-9) → ethyl pyrrolidine-3-carboxylate hydrochloride (80028-44-0,1807350-90-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 48 percent / borane / tetrahydrofuran / 0.25 h

2: 1.) hydrogen, 2.) HCl / 1.) 5percent palladim on carbon / 1.) ethanol, 40 psi, 48 h, 2.) ethanol

With hydrogenchloride; borane; hydrogen; palladium on activated charcoal; In tetrahydrofuran;

DOI:10.1021/ja00367a025

Reference yield:

1-benzyl-3-carboethoxypyrrolidine (5747-92-2) → ethyl pyrrolidine-3-carboxylate hydrochloride (80028-44-0,1807350-90-8)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; Yield given. Multistep reaction; 1.) ethanol, 40 psi, 48 h, 2.) ethanol;

DOI:10.1021/ja00367a025

upstream raw materials:

1-benzyl-3-carboethoxypyrrolidine

1-benzyl-3-(ethoxycarbonyl)-5-pyrrolidinone

1-t-butyloxycarbonylpyrrole-3-carboxylic acid ethyl ester

1-boc-pyrrolidine-3-carboxylic acid

Downstream raw materials:

1-(4-pyridyl)-3-pyrrolidinecarboxylic acid

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