4,6'-Dichloro-2,2'-bipyridine

Base Information

• Chemical Name: 4,6'-Dichloro-2,2'-bipyridine
• CAS No.: 85591-65-7
• Molecular Formula: C₁₀H₆Cl₂N₂
• Molecular Weight: 225.077
• DSSTox Substance ID: DTXSID80517404
• Wikidata: Q72465701
• Mol file: 85591-65-7.mol

Synonyms:4,6'-DICHLORO-2,2'-BIPYRIDINE;85591-65-7;2-chloro-6-(4-chloropyridin-2-yl)pyridine;DTXSID80517404;FT-0724270;J-400526

Chemical Property of 4,6'-Dichloro-2,2'-bipyridine

Chemical Property:

• Melting Point: 87.5-89℃ (ligroine )
• Density: 1.363±0.06 g/cm3 (20 oC 760 Torr)
• Storage Temp.: 2-8°C
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 223.9908036
• Heavy Atom Count: 14
• Complexity: 189

Purity/Quality:

99.0% ^*data from raw suppliers

4,6'-Dichloro-2,2'-bipyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC(=C1)Cl)C2=NC=CC(=C2)Cl

Technology Process of 4,6'-Dichloro-2,2'-bipyridine

There total 2 articles about 4,6'-Dichloro-2,2'-bipyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

4'-nitro-2,2'-bipyridine-N-oxide (84175-05-3) → 4,4'-dichloro-2,2'-bipyridine (1762-41-0) + 4,6'-dichloro-2,2'-bipyridine (85591-65-7)

Guidance literature:

With trichlorophosphate; at 80 ℃; for 4h;

DOI:10.1016/j.tet.2016.10.006

Reference yield: 20.0%

[2,2']bipyridinyl 1,1'-dioxide (7275-43-6) → 4,4'-dichloro-2,2'-bipyridine (1762-41-0) + 4,6'-dichloro-2,2'-bipyridine (85591-65-7) + 6,6'-dichloro-2,2'-bipyridine (53344-72-2)

Guidance literature:

With trichlorophosphate; for 5h; Heating;

DOI:10.1016/S0040-4020(01)91821-6

upstream raw materials:

[2,2']bipyridinyl 1,1'-dioxide

4'-nitro-2,2'-bipyridine-N-oxide