59262-86-1Relevant academic research and scientific papers
Screening solution-phase combinatorial libraries using pulsed ultrafiltration/electrospray mass spectrometry
Zhao, Yong-Zhong,Van Breemen, Richard B.,Nikolic, Dejan,Huang, Chao-Ran,Woodbury, Charles P.,Schilling, Alexander,Venton, Duane L.
, p. 4006 - 4012 (2007/10/03)
A method is described whereby a family of homologues is synthesized in a one-pot reaction, without isolation or purification, and the reaction mixture is screened using a competitive binding assay based on pulsed ultrafiltration/electrospray mass spectrom
Method of imparting immunomodulating and antiviral activity
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, (2008/06/13)
Compounds of the formula STR1 where X is OH, NH2, SH, OR or SR (where R is alkyl of 1 to 4 carbon atoms or benzyl), R1 is H or alkyl of 1 to 8 carbon atoms, R2 is H or methyl, Y is the salt of an amine of the formula STR2 where R3 and R4 are lower alkyl, e.g., 1 to 4 carbon atoms and n is an integer of 2 to 4 with p-acetamidobenzoic acid and where z is a number from 0 to 10 are useful as immunomodulators, as antiviral agents and in specific cases have anti-leukemic activity. The compounds and compositions where z is 1 to 10 are novel per se. When R2 is H the presence of Y enhances the immunoregulatory activity and the antiviral activity. If X is the NH2 there is immunoinhibitory activity but no immunostimulatory (immunopotentiatory) activity.
9-(Hydroxy alkyl)purines
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, (2008/06/13)
There are prepared compounds of the formula STR1 where X is OH, R2 is CH3 and R1 is alkyl of 1 to 8 carbon atoms. The compounds are immunopotentiators, have antiviral activity and anti-leukemic activity.
