Aminooxy-PEG2-azide

Base Information

• Chemical Name: Aminooxy-PEG2-azide
• CAS No.: 1043426-13-6
• Molecular Formula: C₆H₁₄N₄O₃
• Molecular Weight: 190.202
• Mol file: 1043426-13-6.mol

Synonyms:

Chemical Property of Aminooxy-PEG2-azide

Chemical Property:

• Solubility.: Soluble in Water, DMSO, DMF, DCM

Purity/Quality:

99% ^*data from raw suppliers

Aminooxy-PEG2-azide 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Aminooxy-PEG2-azide contain an azide and an aminooxy group. The aminooxy group reacts with an aldehyde or ketone group to form a oxime linkage. The azide group enables Click Chemistry. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.

Technology Process of Aminooxy-PEG2-azide

There total 3 articles about Aminooxy-PEG2-azide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(2[2-[2-azidoethoxy]ethoxy]ethoxy)phthalimide (1374225-43-0) → C6H14N4O3 (1043426-13-6)

Guidance literature:

With hydrazine hydrate; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ja300893t

Reference yield:

N-(2[2-[2-chloroethoxy]ethoxy]ethoxy)phthalimide (1374225-42-9) → C6H14N4O3 (1043426-13-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide; potassium iodide / N,N-dimethyl-formamide / 48 h / 80 °C / Inert atmosphere

2: hydrazine hydrate / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With sodium azide; hydrazine hydrate; potassium iodide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja300893t

Reference yield:

2-[2-(chloroethoxy)ethoxy]ethanol (5197-62-6) → C6H14N4O3 (1043426-13-6)

Guidance literature:

Multi-step reaction with 3 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: sodium azide; potassium iodide / N,N-dimethyl-formamide / 48 h / 80 °C / Inert atmosphere

3: hydrazine hydrate / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With sodium azide; di-isopropyl azodicarboxylate; hydrazine hydrate; triphenylphosphine; potassium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: Mitsunobu reaction;

DOI:10.1021/ja300893t

upstream raw materials:

N-(2[2-[2-chloroethoxy]ethoxy]ethoxy)phthalimide

N-(2[2-[2-azidoethoxy]ethoxy]ethoxy)phthalimide

2-[2-(chloroethoxy)ethoxy]ethanol

Refernces