tertiary-butyloxycarbonyl-L-iodotyrosine-N-hydroxysuccininimide ester

Base Information

Chemical Name:tertiary-butyloxycarbonyl-L-iodotyrosine-N-hydroxysuccininimide ester
CAS No.:79028-57-2
Molecular Formula:C18H21 I N2 O7
Molecular Weight:504.27301
Hs Code.:
Mol file:79028-57-2.mol

Synonyms:tertiary-butyloxycarbonyl-L-iodotyrosine-N-hydroxysuccininimide ester

Suppliers and Price of tertiary-butyloxycarbonyl-L-iodotyrosine-N-hydroxysuccininimide ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 3 raw suppliers

Chemical Property of tertiary-butyloxycarbonyl-L-iodotyrosine-N-hydroxysuccininimide ester

Chemical Property:

Melting Point:169 - 170 °C (propan-2-ol)
PSA：122.24000
Density:1.68g/cm³
LogP:2.36860

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of tertiary-butyloxycarbonyl-L-iodotyrosine-N-hydroxysuccininimide ester

There total 5 articles about tertiary-butyloxycarbonyl-L-iodotyrosine-N-hydroxysuccininimide ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 71400-63-0,478183-68-5
N-tert-butyloxycarbonyl-3-iodo-L-tyrosine

: 79028-57-2
(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-3-iodo-phenyl)-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In 1,4-dioxane; at 3 ℃; for 18h;
DOI:10.1002/jlac.198119810716

Reference yield:

: 1070-19-5
N-(tert-butyloxycarbonyl) azide

: 79028-57-2
(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-3-iodo-phenyl)-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1) NH₃ / 1) chloroform, 30 min, 2) pyridine, 4,5 days

2: 2 N NaOH / acetone / 2 h / Ambient temperature

3: 83 percent / DCCI / dioxane / 18 h / 3 °C

With sodium hydroxide; ammonia; dicyclohexyl-carbodiimide; In 1,4-dioxane; acetone;
DOI:10.1002/jlac.198119810716

Reference yield:

: 70-78-0
3-Iodo-L-tyrosine

: 79028-57-2
(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-3-iodo-phenyl)-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / SOCl₂ / methanol / 41 h / 20 °C

2: 1) NH₃ / 1) chloroform, 30 min, 2) pyridine, 4,5 days

3: 2 N NaOH / acetone / 2 h / Ambient temperature

4: 83 percent / DCCI / dioxane / 18 h / 3 °C

With sodium hydroxide; thionyl chloride; ammonia; dicyclohexyl-carbodiimide; In 1,4-dioxane; methanol; acetone;
DOI:10.1002/jlac.198119810716