α-Methyl-4-nitro-benzenepropanaMine

Base Information

• Chemical Name: α-Methyl-4-nitro-benzenepropanaMine
• CAS No.: 99721-51-4
• Molecular Formula: C₁₀H₁₄N₂O₂
• Molecular Weight: 194.233
• Mol file: 99721-51-4.mol

Synonyms:

Chemical Property of α-Methyl-4-nitro-benzenepropanaMine

Chemical Property:

• Solubility.: Chloroform, Dichloromethane

Purity/Quality:

α-Methyl-4-nitro-benzenepropanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: A reactant used in the preparation of β-Phenethanolamine antiobesity agents. α-Methyl-4-nitro-benzenepropanaMine is a reactant used in the preparation of β-Phenethanolamine antiobesity agents.

Technology Process of α-Methyl-4-nitro-benzenepropanaMine

There total 6 articles about α-Methyl-4-nitro-benzenepropanaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.7%

4-(4-nitrophenyl)butan-2-one (30780-19-9) → 4-(4-nitrophenyl)butan-2-amine (99721-51-4)

Guidance literature:

4-(4-nitrophenyl)butan-2-one; With ammonia; In 1,4-dioxane; at 20 ℃; for 12h;

With potassium borohydride; In 1,4-dioxane; for 3h; Solvent; Reagent/catalyst; Cooling with ice;

Reference yield:

(RS)-1-methyl-3-phenylpropylamine (22374-89-6,22148-77-2,1199266-89-1) → 4-(4-nitrophenyl)butan-2-amine (99721-51-4) + 4-(2-nitrophenyl)-butan-2-amine

Guidance literature:

With nitric acid; at -20 ℃; for 4.5h; Overall yield = 89 %; Overall yield = 140.2 g;

Reference yield:

1-(ethoxycarbonyl)-1-(p-nitrobenzyl)-2-propanone (61713-40-4) → 4-(4-nitrophenyl)butan-2-amine (99721-51-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid / water / 24 h / 110 °C

2.1: formamide / 5 h / 130 °C

2.2: 1 h / 110 °C

With formamide; acetic acid; In water;

upstream raw materials:

4-(4-nitrophenyl)butan-2-one

1-(ethoxycarbonyl)-1-(p-nitrobenzyl)-2-propanone

1-bromomethyl-4-nitro-benzene

(RS)-1-methyl-3-phenylpropylamine

Refernces

• 1、 -. "Synthetic method of phenylethanolamine A". Paragraph 0023; 0032-0034. . Retrieved 2019/05/28.
• 2、 -. "Method for preparing phenylethanolamine compound intermediate". Paragraph 0105; 0109. . Retrieved 2018/05/07.