61713-40-4

Upstream product

• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 7409-30-5 p-nitrobenzylamine 
• 141-97-9 ethyl acetoacetate 
• 620-79-1 Ethyl 2-benzylacetoacetate 

Downstream Products

• 91093-10-6 3-(4-nitrobenzyl)tetrahydrofuran-2,4-dione 
• 99972-88-0 3-(4-Nitrobenzyl)tetronsaeure 
• 99721-51-4 4-(4-nitrophenyl)butan-2-amine 
• 1346746-81-3 phenylethanol-amine A 
• 1598386-30-1 2-[4-(carboxymethyl)-7-[2-hydroxy-4-(4-nitrophenyl)butyl]-1,4,7-triazanonan-1-yl]acetic acid 
• 1598386-27-6 2-[4-(carboxymethyl)-7-[4-(4-nitrophenyl)-2-oxobutyl]-1,4,7-triazanonan-1-yl]acetic acid 
• 1598386-23-2 tert-butyl 2-{4-[2-(tert-butoxy)-2-oxoethyl]-7-[2-hydroxy-4-(4-nitrophenyl)butyl]-1,4,7-triazanonan-1-yl}acetate 
• 1598386-22-1 tert-butyl 2-{4-[2-(tert-butoxy)-2-oxoethyl]-7-[4-(4-nitrophenyl)-2-oxobutyl]-1,4,7-triazanonan-1-yl}acetate 
• 1598386-21-0 1-bromo-4-(4-nitrophenyl)butan-2-one 
• 30780-19-9 4-(4-nitrophenyl)butan-2-one 
• 1237543-06-4 ethyl 2-(tert-butylperoxy)-2-(4-nitrobenzyl)-3-oxobutanoate 
• 219552-31-5 5,7-Dihydroxy-4-methyl-3-(4-nitrobenzyl)-2H-1-benzopyran-2-one 

Relevant academic research and scientific papers

Synthesis of α-Nitro Carbonyls via Nitrations in Flow

Reported is a safe, rapid method for the synthesis of α-nitro esters via the trapping of nitronium ions. The two-stage nitration and subsequent deacetylation of readily available 1,3-dicarbonyl compounds was achieved using a biphasic semicontinuous approach. α-Nitro esters and amides were obtained in good overall yields (53-84%). Some of the α-nitro-1,3-dicarbonyl intermediates exhibit enhanced reactivity and undergo an acid-catalyzed Nef-type reaction to α-oxo-carbonyls.

Synthetic method of phenylethanolamine A

The invention discloses a method for preparing phenylethanolamine A. The method includes the following steps: 1) reacting p-methoxyacetophenone in an HBr/DMSO system to obtain acetophenone aldehyde monohydrate and acetophenone aldehyde; 2) subjecting the acetophenone aldehyde and 4(4-nitrophenyl)butane-2-amine to bimolecular substitution reaction, and subjecting an intermediate product obtained bythe reaction to reduction reaction by potassium borohydride to obtain the phenylethanolamine A. The method has the advantages that the reactions are simple, the reaction steps are reduced, and the high-yield phenylethanolamine A is obtained.

p27 PROTEIN INDUCER

The present invention provides a p27 protein inducing agent comprising a compound represented by general formula (11) below or pharmaceutically acceptable salt thereof as an active ingredient: wherein G 1 , G 2 , G 3 and G 8 are each independently selected from -N= etc., Ring G 6 is selected from divalent aryl etc., A is selected from amino etc., G 4 is selected from oxygen etc., G 5 is selected from oxygen etc., G 7 is selected from -CH 2 - etc., and R 2 is selected from C 1-6 alkyl etc.

p27 PROTEIN INDUCER

The present invention provides a p27 protein inducing agent comprising a compound represented by general formula (11) below or pharmaceutically acceptable salt thereof as an active ingredient: wherein G1, G2, G3 and G8 are each independently selected from -N= etc., Ring G6 is selected from divalent aryl etc., A is selected from amino etc., G4 is selected from oxygen etc., G5 is selected from oxygen etc., G7 is selected from -CH2- etc., and R2 is selected from C1-6 alkyl etc.

NOVEL COUMARIN DERIVATIVE HAVING ANTITUMOR ACTIVITY

The present invention provides a compound represented by general formula (1) below or a pharmaceutically acceptable salt thereof: wherein: X is selected from heteroaryl etc., Y1 and Y2 are selected from -N= etc., Y3 and Y4 are selected from -CH= etc., A is selected from sulfamide etc., R1 is selected from hydrogen etc., and R2 is selected from C1-6 alkyl etc. The compound or salt has sufficiently high antitumor activity, and is useful in the treatment of cell proliferative disorders, particularly cancers. The present invention also provides a pharmaceutical composition containing the compound or salt as an active ingredient.