61713-40-4

Basic information

• Product Name: 1-(ethoxycarbonyl)-1-(p-nitrobenzyl)-2-propanone
• Synonyms: 1-(ethoxycarbonyl)-1-(p-nitrobenzyl)-2-propanone
• CAS NO: 61713-40-4
• Molecular Weight: 265.266
• Mol File: 61713-40-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-(ethoxycarbonyl)-1-(p-nitrobenzyl)-2-propanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(ethoxycarbonyl)-1-(p-nitrobenzyl)-2-propanone(61713-40-4)
• EPA Substance Registry System: 1-(ethoxycarbonyl)-1-(p-nitrobenzyl)-2-propanone(61713-40-4)

Safety Data

• Hazardous Substances Data: 61713-40-4(Hazardous Substances Data)

Upstream product

• 7409-30-5 p-nitrobenzylamine 
• 141-97-9 ethyl acetoacetate 
• 620-79-1 Ethyl 2-benzylacetoacetate 
• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 100-11-8 1-bromomethyl-4-nitro-benzene 

Downstream Products

• 99972-88-0 3-(4-Nitrobenzyl)tetronsaeure 
• 1237543-06-4 ethyl 2-(tert-butylperoxy)-2-(4-nitrobenzyl)-3-oxobutanoate 
• 99721-51-4 4-(4-nitrophenyl)butan-2-amine 
• 1346746-81-3 phenylethanol-amine A 
• 1598386-30-1 2-[4-(carboxymethyl)-7-[2-hydroxy-4-(4-nitrophenyl)butyl]-1,4,7-triazanonan-1-yl]acetic acid 
• 1598386-27-6 2-[4-(carboxymethyl)-7-[4-(4-nitrophenyl)-2-oxobutyl]-1,4,7-triazanonan-1-yl]acetic acid 
• 1598386-23-2 tert-butyl 2-{4-[2-(tert-butoxy)-2-oxoethyl]-7-[2-hydroxy-4-(4-nitrophenyl)butyl]-1,4,7-triazanonan-1-yl}acetate 
• 1598386-22-1 tert-butyl 2-{4-[2-(tert-butoxy)-2-oxoethyl]-7-[4-(4-nitrophenyl)-2-oxobutyl]-1,4,7-triazanonan-1-yl}acetate 
• 1598386-21-0 1-bromo-4-(4-nitrophenyl)butan-2-one 
• 30780-19-9 4-(4-nitrophenyl)butan-2-one 
• 219552-31-5 5,7-Dihydroxy-4-methyl-3-(4-nitrobenzyl)-2H-1-benzopyran-2-one 
• 95314-50-4 C₁₉H₁₇N₄O₁₁^(1-)*C₆H₁₅N*H⁽¹⁺⁾ 
• 91093-10-6 3-(4-nitrobenzyl)tetrahydrofuran-2,4-dione 

Relevant articles and documents

Synthesis of α-Nitro Carbonyls via Nitrations in Flow

Reported is a safe, rapid method for the synthesis of α-nitro esters via the trapping of nitronium ions. The two-stage nitration and subsequent deacetylation of readily available 1,3-dicarbonyl compounds was achieved using a biphasic semicontinuous approach. α-Nitro esters and amides were obtained in good overall yields (53-84%). Some of the α-nitro-1,3-dicarbonyl intermediates exhibit enhanced reactivity and undergo an acid-catalyzed Nef-type reaction to α-oxo-carbonyls.

p27 PROTEIN INDUCER

The present invention provides a p27 protein inducing agent comprising a compound represented by general formula (11) below or pharmaceutically acceptable salt thereof as an active ingredient: wherein G 1 , G 2 , G 3 and G 8 are each independently selected from -N= etc., Ring G 6 is selected from divalent aryl etc., A is selected from amino etc., G 4 is selected from oxygen etc., G 5 is selected from oxygen etc., G 7 is selected from -CH 2 - etc., and R 2 is selected from C 1-6 alkyl etc.

NOVEL COUMARIN DERIVATIVE HAVING ANTITUMOR ACTIVITY

The present invention provides a compound represented by general formula (1) below or a pharmaceutically acceptable salt thereof: wherein: X is selected from heteroaryl etc., Y1 and Y2 are selected from -N= etc., Y3 and Y4 are selected from -CH= etc., A is selected from sulfamide etc., R1 is selected from hydrogen etc., and R2 is selected from C1-6 alkyl etc. The compound or salt has sufficiently high antitumor activity, and is useful in the treatment of cell proliferative disorders, particularly cancers. The present invention also provides a pharmaceutical composition containing the compound or salt as an active ingredient.