(2S)-2-tert-Butyloxy-butanedioic Acid tert-Butyl Ethyl Ester

Base Information

• Chemical Name: (2S)-2-tert-Butyloxy-butanedioic Acid tert-Butyl Ethyl Ester
• CAS No.: 958350-60-2
• Molecular Formula: C₁₄H₂₆O₅
• Molecular Weight: 274.357
• Mol file: 958350-60-2.mol

Synonyms:

Chemical Property of (2S)-2-tert-Butyloxy-butanedioic Acid tert-Butyl Ethyl Ester

Chemical Property:

• Solubility.: Dichloromethane, Ethyl Acetate

Purity/Quality:

(2S)-2-tert-Butyloxy-butanedioicAcidtert-ButylEthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (2S)-2-tert-Butyloxy-butanedioic Acid tert-Butyl Ethyl Ester is a reactant used in the preparation of 2’-Deoxymugineic Acid (D243250). A reactant used in the preparation of 2’-Deoxymugineic Acid (D243250).

Technology Process of (2S)-2-tert-Butyloxy-butanedioic Acid tert-Butyl Ethyl Ester

There total 3 articles about (2S)-2-tert-Butyloxy-butanedioic Acid tert-Butyl Ethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

isobutene (115-11-7,15220-85-6) + (S)-4-ethoxy-2-hydroxy-4-oxobutanoic acid (225933-67-5,15690-37-6) → 1-(tert-butyl) 4-ethyl (S)-2-(tert-butoxy)succinate (958350-60-2)

Guidance literature:

isobutene; (S)-4-ethoxy-2-hydroxy-4-oxobutanoic acid; In dichloromethane; for 0.0333333h; Inert atmosphere;

With sulfuric acid; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere; Sealed tube;

DOI:10.1002/chem.202004004

Reference yield: 19.0%

isobutene (115-11-7,15220-85-6) + (S)-4-ethoxy-2-hydroxy-4-oxobutanoic acid (225933-67-5,15690-37-6) → 1-(tert-butyl) 4-ethyl (S)-2-(tert-butoxy)succinate (958350-60-2) + C10H18O5

Guidance literature:

With sulfuric acid; In dichloromethane; at 20 ℃;

DOI:10.1002/jlcr.3242

Reference yield:

ethyl (S)-2-(2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl)acetate → 1-(tert-butyl) 4-ethyl (S)-2-(tert-butoxy)succinate (958350-60-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid / water / 1.5 h / 100 °C

2.1: dichloromethane / 0.03 h / Inert atmosphere

2.2: 4 h / 20 °C / Inert atmosphere; Sealed tube

With acetic acid; In dichloromethane; water;

DOI:10.1002/chem.202004004

upstream raw materials:

isobutene

(S)-4-ethoxy-2-hydroxy-4-oxobutanoic acid