Technology Process of (10E)-4,6,10-trimethoxy-2-oxatricyclo-[13.2.2.13,7]icosa-1(17),3,5,7(20),10,15,18-heptaen-12-one
There total 9 articles about (10E)-4,6,10-trimethoxy-2-oxatricyclo-[13.2.2.13,7]icosa-1(17),3,5,7(20),10,15,18-heptaen-12-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: diisobutylaluminium hydride / dichloromethane; toluene / 0.5 h / -78 °C / Inert atmosphere
2.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 1.5 h / -78 °C / Inert atmosphere
2.2: 3 h / -78 °C / Inert atmosphere
3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / Inert atmosphere; Reflux
4.1: pentamethylbenzene,; boron trichloride / dichloromethane / 0.17 h / -78 °C / Inert atmosphere
5.1: copper(II) oxide; pyridine; potassium carbonate / 36 h / 120 °C / Inert atmosphere; Sealed tube
6.1: hexane; acetonitrile; methanol / 4 h / 20 °C / Inert atmosphere
6.2: 0.08 h / Inert atmosphere; Acidic conditions; Molecular sieve
With
pyridine; n-butyllithium; pentamethylbenzene,; boron trichloride; diisobutylaluminium hydride; potassium carbonate; diisopropylamine; copper(II) oxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; methanol; hexane; dichloromethane; ethyl acetate; toluene; acetonitrile;
5.1: |Ullmann Condensation;
DOI:10.1021/jo400157d
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 1.5 h / -78 °C / Inert atmosphere
1.2: 3 h / -78 °C / Inert atmosphere
2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / Inert atmosphere; Reflux
3.1: pentamethylbenzene,; boron trichloride / dichloromethane / 0.17 h / -78 °C / Inert atmosphere
4.1: copper(II) oxide; pyridine; potassium carbonate / 36 h / 120 °C / Inert atmosphere; Sealed tube
5.1: hexane; acetonitrile; methanol / 4 h / 20 °C / Inert atmosphere
5.2: 0.08 h / Inert atmosphere; Acidic conditions; Molecular sieve
With
pyridine; n-butyllithium; pentamethylbenzene,; boron trichloride; potassium carbonate; diisopropylamine; copper(II) oxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; methanol; hexane; dichloromethane; ethyl acetate; acetonitrile;
4.1: |Ullmann Condensation;
DOI:10.1021/jo400157d
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / Inert atmosphere; Reflux
2.1: pentamethylbenzene,; boron trichloride / dichloromethane / 0.17 h / -78 °C / Inert atmosphere
3.1: copper(II) oxide; pyridine; potassium carbonate / 36 h / 120 °C / Inert atmosphere; Sealed tube
4.1: hexane; acetonitrile; methanol / 4 h / 20 °C / Inert atmosphere
4.2: 0.08 h / Inert atmosphere; Acidic conditions; Molecular sieve
With
pyridine; pentamethylbenzene,; boron trichloride; potassium carbonate; copper(II) oxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
methanol; hexane; dichloromethane; ethyl acetate; acetonitrile;
3.1: |Ullmann Condensation;
DOI:10.1021/jo400157d
