Technology Process of (11E)-4,6,12-Trimethoxy-2-oxatricyclo[13.2.2.13,7]icosa-3,5,7(20),11,15,17(1),18-heptaen-10-one
There total 18 articles about (11E)-4,6,12-Trimethoxy-2-oxatricyclo[13.2.2.13,7]icosa-3,5,7(20),11,15,17(1),18-heptaen-10-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
In
methanol;
at 60 ℃;
for 72h;
Inert atmosphere;
DOI:10.1021/jo400157d
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: diisobutylaluminium hydride / dichloromethane; toluene / 0.5 h / -78 °C / Inert atmosphere
2.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 1.5 h / -78 °C / Inert atmosphere
2.2: 3 h / -78 °C / Inert atmosphere
3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / Inert atmosphere; Reflux
4.1: pentamethylbenzene,; boron trichloride / dichloromethane / 0.17 h / -78 °C / Inert atmosphere
5.1: copper(II) oxide; pyridine; potassium carbonate / 36 h / 120 °C / Inert atmosphere; Sealed tube
6.1: toluene-4-sulfonic acid / methanol / 72 h / 60 °C / Inert atmosphere
With
pyridine; n-butyllithium; pentamethylbenzene,; boron trichloride; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; diisopropylamine; copper(II) oxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; methanol; hexane; dichloromethane; ethyl acetate; toluene;
5.1: |Ullmann Condensation;
DOI:10.1021/jo400157d
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 1.5 h / -78 °C / Inert atmosphere
1.2: 3 h / -78 °C / Inert atmosphere
2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / Inert atmosphere; Reflux
3.1: pentamethylbenzene,; boron trichloride / dichloromethane / 0.17 h / -78 °C / Inert atmosphere
4.1: copper(II) oxide; pyridine; potassium carbonate / 36 h / 120 °C / Inert atmosphere; Sealed tube
5.1: toluene-4-sulfonic acid / methanol / 72 h / 60 °C / Inert atmosphere
With
pyridine; n-butyllithium; pentamethylbenzene,; boron trichloride; potassium carbonate; toluene-4-sulfonic acid; diisopropylamine; copper(II) oxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; methanol; hexane; dichloromethane; ethyl acetate;
4.1: |Ullmann Condensation;
DOI:10.1021/jo400157d
