(3R,4R,5S)-5-(acetylamino)-4-amino-3-(pentan-3-yloxy) cyclohex-1-ene-1-carboxylic acid

Base Information

Chemical Name:(3R,4R,5S)-5-(acetylamino)-4-amino-3-(pentan-3-yloxy) cyclohex-1-ene-1-carboxylic acid
CAS No.:1391047-93-0
Molecular Formula:C₁₄H₂₄N₂O₄
Molecular Weight:284.356
Hs Code.:

Synonyms:

Suppliers and Price of (3R,4R,5S)-5-(acetylamino)-4-amino-3-(pentan-3-yloxy) cyclohex-1-ene-1-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-N-Desacetyl-5-N-acetylOseltamivirAcid
2.5mg
$ 165.00

Total 5 raw suppliers

Chemical Property of (3R,4R,5S)-5-(acetylamino)-4-amino-3-(pentan-3-yloxy) cyclohex-1-ene-1-carboxylic acid

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

4-N-Desacetyl-5-N-acetylOseltamivirAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 4-N-Desacetyl-5-N-acetyl Oseltamivir Acid (Oseltamivir EP Impurity A) is an impurity of the antiviral drug Oseltamivir (O701000). It is a COVID19-related research product.

Technology Process of (3R,4R,5S)-5-(acetylamino)-4-amino-3-(pentan-3-yloxy) cyclohex-1-ene-1-carboxylic acid

There total 8 articles about (3R,4R,5S)-5-(acetylamino)-4-amino-3-(pentan-3-yloxy) cyclohex-1-ene-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: (3R,4R,5S)-5-(acetylamino)-4-[(tert-butoxycarbonyl)amino]-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid

: 1364932-19-3,1391047-93-0
(3R,4R,5S)-5-(acetylamino)-4-amino-3-(pentan-3-yloxy) cyclohex-1-ene-1-carboxylic acid

Guidance literature:: With isopropyl alcohol hydrogen chloride; In dichloromethane; at 0 - 30 ℃; for 5h;
DOI:10.14233/ajchem.2018.21376

Reference yield:

: 196618-13-0
oseltamivir

: 187227-45-8
oseltamivir acid

: 1364932-19-3,1391047-93-0
(3R,4R,5S)-5-(acetylamino)-4-amino-3-(pentan-3-yloxy) cyclohex-1-ene-1-carboxylic acid

: ethyl-(3R,4R,5S)-5-(acetylamino)-4-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate

Guidance literature:: In water; at 70 ℃; pH=2 - 8; Kinetics; Product distribution;
DOI:10.1023/A:1011964529805

Reference yield:

: 204254-96-6,1217834-81-5,1266663-89-1,2413185-89-2
(1S,5R,6S)-5-(pentan-3-yloxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylic acid ethyl ester

: 1364932-19-3,1391047-93-0
(3R,4R,5S)-5-(acetylamino)-4-amino-3-(pentan-3-yloxy) cyclohex-1-ene-1-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1: ammonium chloride; sodium azide / methanol; water / 65 - 70 °C

2: triphenylphosphine / acetonitrile / 3.25 h / 20 - 80 °C

3: ammonium chloride; sodium azide / N,N-dimethyl-formamide / 16 h / 65 - 70 °C

4: triethylamine / dichloromethane / 16 h / 0 - 20 °C

5: triphenylphosphine / tetrahydrofuran / 16 h / 25 - 30 °C

6: potassium carbonate / tetrahydrofuran / 4 h / 20 °C

7: lithium hydroxide monohydrate / water; tetrahydrofuran / 7 h / 20 °C

8: isopropyl alcohol hydrogen chloride / dichloromethane / 5 h / 0 - 30 °C

With sodium azide; isopropyl alcohol hydrogen chloride; lithium hydroxide monohydrate; potassium carbonate; ammonium chloride; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.14233/ajchem.2018.21376