Oseltamivir

Base Information Edit

Chemical Name:Oseltamivir
CAS No.:196618-13-0
Molecular Formula:C16H28N2O4
Molecular Weight:312.409
Hs Code.:
UNII:20O93L6F9H
DSSTox Substance ID:DTXSID9044291
Nikkaji Number:J871.765F
Wikipedia:Oseltamivir
Wikidata:Q211509
NCI Thesaurus Code:C62061
Metabolomics Workbench ID:42605
ChEMBL ID:CHEMBL1229
Mol file:196618-13-0.mol

Synonyms:GS 4071;GS 4104;GS-4071;GS-4104;GS4071;GS4104;Oseltamivir;Tamiflu

Suppliers and Price of Oseltamivir

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Oseltamivir
100mg
$ 418.00

TRC
Oseltamivir
500mg
$ 580.00

Crysdot
(3R,4R,5S)-Ethyl4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate 97%
50mg
$ 258.00

Chemtos
Oseltamivir phosphate
50 mg
$ 1100.00

Chemenu
Ethyl(3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate 97%
10g
$ 608.00

Chemenu
Ethyl(3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate 97%
5g
$ 355.00

Biorbyt Ltd
OSELTAMIVIR >98%
1 g
$ 542.30

AvaChem
Oseltamivir
10g
$ 390.00

AvaChem
Oseltamivir
100mg
$ 49.00

AvaChem
Oseltamivir
1g
$ 89.00

Total 109 raw suppliers

Chemical Property of Oseltamivir Edit

Chemical Property:

Vapor Pressure:3.98E-09mmHg at 25°C
Melting Point:107-108 °C
Refractive Index:1.502
Boiling Point:473.3 °C at 760 mmHg
PKA:7.7 (25°); 6.6 (70°)
Flash Point:240 °C
PSA：90.65000
Density:1.08 g/cm³
LogP:2.37660
Storage Temp.:2-8°C(protect from light)
Solubility.:Chloroform (Sparingly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Sli
XLogP3:1.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:312.20490738
Heavy Atom Count:22
Complexity:418

Purity/Quality:

99% ^*data from raw suppliers

Oseltamivir ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Drug Classes:Antiviral Agents
Canonical SMILES:CCC(CC)OC1C=C(CC(C1NC(=O)C)N)C(=O)OCC
Isomeric SMILES:CCC(CC)O[C@@H]1C=C(C[C@@H]([C@H]1NC(=O)C)N)C(=O)OCC
Recent ClinicalTrials:Efficacy and Safety of Molnupiravir in Healthy Participants Inoculated With Experimental Influenza Virus (MK-4482-019)
Recent EU Clinical Trials:Irbesartan and Oseltamivir treatment of COVID-19 infection.
Recent NIPH Clinical Trials:open-label, active-controlled study of baloxavir in pediatric patients with influenza
Description Oseltamivir is a drug that suppresses the action of influenza A, influenza B, and H1N1 influenza viruses in children and adults. Oseltamivir is administered for the treatment of influenza (flu) for people who are above the age of 2 weeks and have been experiencing flu-like symptoms for less than two days. Oseltamivir may also be prescribed for people who are above 1-year-old as a protective measure to prevent them from contracting influenza due to exposure to the virus without necessarily having indicated any symptoms of infection. The drug may not treat common cold. Oseltamivir goes by the brand name Tamiflu.
Indications Oseltamivir is prescribed for the treatment of mild or severe illness that results from infection with influenza A or B virus for patients above the age of 2 weeks, and have been experiencing flu-like symptoms for less than 48 hours. The drug is also used for preventive treatment against influenza amongst adolescents above 13 years and adults. Oseltamivir phosphate (Tamiflu) is the ethyl ester prodrug of oseltamivir carboxylate, an analogue of neuraminic (sialic) acid that is a reversible competitive antagonist of influenza A and B neuraminidase.Influenza virus resistant to oseltamivir has not been found in naturally acquired isolates but has been isolated from influenza patients who have undergone treatment with this drug.These resistant strains contain mutations in the active site of neuraminidase and are generally less virulent and infective than nonresistant virus. In vitro passage of influenza virus in the presence of oseltamivir carboxylate can produce mutations in hemagglutinin that decrease the overall dependence of viral replication on neuraminidase; however, the clinical relevance of this resistance mechanism is unknown.
Uses Oseltamivir is an orally active inhibitor of influenza virus neuraminidase; converted in vivo to the active acid metabolite. An antiviral drug. It is a COVID19-related research product.
Therapeutic Function Antiviral
Clinical Use Treatment and prevention of susceptible influenza A (H3N2) and B infections in adults and young children Oseltamivir is approved for the treatment of uncomplicated acute influenza in patients aged 1 year and older. It decreases the duration of illness by 1 to 1.5 days when treatment is initiated within 48 hours of the onset of symptoms. Oseltamivir is also indicated for the prophylaxis of influenza in individuals aged 13 and older. It reduces infection rates to approximately 10 to 25% of that found in untreated populations; however, it is not intended to substitute for the early vaccination recommended by the CDC. Oseltamivir can be used as postexposure prophylaxis in household contacts of infected patients, with infection rates of treated patients around 10% of placebo control levels.
Drug interactions Potentially hazardous interactions with other drugs None known

Technology Process of Oseltamivir

There total 195 articles about Oseltamivir which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%