5-tert-Butyl-4H-[1,2,4]triazole-3-carboxylic acid

Base Information

• Chemical Name: 5-tert-Butyl-4H-[1,2,4]triazole-3-carboxylic acid
• CAS No.: 1240492-43-6
• Molecular Formula: C₁₅H₂₁BO₂
• Molecular Weight: 244.142
• Mol file: 1240492-43-6.mol

Synonyms:

Chemical Property of 5-tert-Butyl-4H-[1,2,4]triazole-3-carboxylic acid

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-tert-Butyl-4H-[1,2,4]triazole-3-carboxylic acid

There total 90 articles about 5-tert-Butyl-4H-[1,2,4]triazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

diisopropyl (E)-3-phenyl-2-propenyl phosphate + bis(pinacol)diborane (73183-34-3) → 4,4,5,5-tetramethyl-2-(2-phenylcyclopropyl)-1,3,2-dioxaborolane (1240492-43-6)

Guidance literature:

bis(pinacol)diborane; With 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; copper(l) chloride; at 20 ℃; for 0.5h; Inert atmosphere;

diisopropyl (E)-3-phenyl-2-propenyl phosphate; With potassium tert-butylate; In tetrahydrofuran; at 50 ℃; for 16h; optical yield given as %de; Inert atmosphere;

DOI:10.1021/ja103783p

Reference yield: 87.0%

bis(pinacol)diborane (73183-34-3) + cinnamyl tert-butyl carbonate (124517-47-1) → racemic 4,4,5,5-tetramethyl-2-((1S,2S)-2-phenylcyclopropyl)-1,3,2-dioxaborolane (1240492-43-6)

Guidance literature:

bis(pinacol)diborane; With iron(III) chloride; 1,3-bis-(diphenylphosphino)propane; potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 1h; Schlenk technique; Inert atmosphere;

cinnamyl tert-butyl carbonate; In tetrahydrofuran; at 65 ℃; for 30h; Reagent/catalyst; Solvent; Catalytic behavior; Schlenk technique; Inert atmosphere;

Reference yield: 86.0%

diiodomethane (75-11-6) + 4,4,5,5-tetramethyl-2-((E)-styryl)-[1,3,2]dioxaborolane (83947-56-2) → 4,4,5,5-tetramethyl-2-(2-phenylcyclopropyl)-1,3,2-dioxaborolane (902757-46-4,1240492-43-6)

Guidance literature:

With diethylzinc; In toluene; at 60 ℃; for 24h; Inert atmosphere;

DOI:10.1002/anie.201908931

upstream raw materials:

diazomethane

4,4,5,5-tetramethyl-2-((E)-styryl)-[1,3,2]dioxaborolane

diiodomethane

pinacol dichloromethylboronic ester