tert-Butyl 1-(2-amino-6-fluorophenyl)piperidin-4-ylcarbamate

Base Information

Chemical Name:tert-Butyl 1-(2-amino-6-fluorophenyl)piperidin-4-ylcarbamate
CAS No.:1233952-35-6
Molecular Formula:C₁₆H₂₄FN₃O₂
Molecular Weight:309.384
Hs Code.:
DSSTox Substance ID:DTXSID101151071
Mol file:1233952-35-6.mol

Synonyms:1233952-35-6;tert-Butyl 1-(2-amino-6-fluorophenyl)piperidin-4-ylcarbamate;tert-butyl N-[1-(2-amino-6-fluorophenyl)piperidin-4-yl]carbamate;DTXSID101151071;KS-5631;tert-Butyl1-(2-amino-6-fluorophenyl)piperidin-4-ylcarbamate;1,1-Dimethylethyl N-[1-(2-amino-6-fluorophenyl)-4-piperidinyl]carbamate

Suppliers and Price of tert-Butyl 1-(2-amino-6-fluorophenyl)piperidin-4-ylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
tert-Butyl1-(2-amino-6-fluorophenyl)piperidin-4-ylcarbamate 95+%
1g
$ 431.00

Chemenu
tert-Butyl1-(2-amino-6-fluorophenyl)piperidin-4-ylcarbamate 95%
1g
$ 407.00

Total 2 raw suppliers

Chemical Property of tert-Butyl 1-(2-amino-6-fluorophenyl)piperidin-4-ylcarbamate

Chemical Property:

Boiling Point:453.8±45.0 °C(Predicted)
PKA:12.24±0.20(Predicted)
Density:1.18±0.1 g/cm3(Predicted)
XLogP3:2.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:309.18525518
Heavy Atom Count:22
Complexity:378

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl1-(2-amino-6-fluorophenyl)piperidin-4-ylcarbamate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC1CCN(CC1)C2=C(C=CC=C2F)N

Technology Process of tert-Butyl 1-(2-amino-6-fluorophenyl)piperidin-4-ylcarbamate

There total 3 articles about tert-Butyl 1-(2-amino-6-fluorophenyl)piperidin-4-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1233951-67-1
[1-(2-fluoro-6-nitrophenyl)piperidin-4-yl]carbamic acid tert-butyl ester

: 1233952-35-6
[1-(2-amino-6-fluorophenyl)piperidin-4-yl]carbamic acid tert-butyl ester

Guidance literature:: With palladium on activated charcoal; hydrogen; In ethanol; for 3h; under 760.051 Torr;

Reference yield:

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 1233952-35-6
[1-(2-amino-6-fluorophenyl)piperidin-4-yl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl acetamide / 18 h / 80 °C

2: hydrogen; palladium on activated charcoal / ethanol / 3 h / 760.05 Torr

With palladium on activated charcoal; hydrogen; potassium carbonate; In ethanol; N,N-dimethyl acetamide;

Reference yield:

: 6921-22-8
1,2-difluoro-3-nitrobenzene

: 1233952-35-6
[1-(2-amino-6-fluorophenyl)piperidin-4-yl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl acetamide / 18 h / 80 °C

2: hydrogen; palladium on activated charcoal / ethanol / 3 h / 760.05 Torr

With palladium on activated charcoal; hydrogen; potassium carbonate; In ethanol; N,N-dimethyl acetamide;