N-methyl-1-(oxetan-3-yl)piperidin-4-amine

Base Information

• Chemical Name: N-methyl-1-(oxetan-3-yl)piperidin-4-amine
• CAS No.: 1416323-12-0
• Molecular Formula: C₉H₁₈N₂O
• Molecular Weight: 170.255
• Mol file: 1416323-12-0.mol

Synonyms:

Chemical Property of N-methyl-1-(oxetan-3-yl)piperidin-4-amine

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Methyl(1-oxetan-3-yl-piperidin-4-yl)amine 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-methyl-1-(oxetan-3-yl)piperidin-4-amine

There total 2 articles about N-methyl-1-(oxetan-3-yl)piperidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C17H24N2O3 → N-methyl-1-(oxetan-3-yl)piperidin-4-amine (1416323-12-0)

Guidance literature:

With palladium hydroxide, 20 wt% on carbon; hydrogen; In methanol; at 20 ℃; for 48h;

DOI:10.1016/j.bmcl.2019.126933

Reference yield:

benzyl N-methyl-N-(4-piperidyl)carbamate (553672-39-2) → N-methyl-1-(oxetan-3-yl)piperidin-4-amine (1416323-12-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 3 h / 20 °C

2: palladium hydroxide, 20 wt% on carbon; hydrogen / methanol / 48 h / 20 °C

With palladium hydroxide, 20 wt% on carbon; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; In methanol; 1,2-dichloro-ethane;

DOI:10.1016/j.bmcl.2019.126933

upstream raw materials:

benzyl N-methyl-N-(4-piperidyl)carbamate