Technology Process of 3-Isoxazolidinone, 5-(hydroxymethyl)-2-phenyl-, (R)-
There total 17 articles about 3-Isoxazolidinone, 5-(hydroxymethyl)-2-phenyl-, (R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium phosphate buffer;
porcine pancreatic lipase;
In
acetone;
for 5h;
DOI:10.1021/jo00036a013
- Guidance literature:
-
Multi-step reaction with 6 steps
1: diethyl ether / 0.25 h
2: 48 percent / aq. sodium bicarbonate / diethyl ether / Ambient temperature
3: 61 percent / NaBH4, LiCl / tetrahydrofuran; methanol / 0.17 h
4: pyridine / CH2Cl2
5: potassium phosphate buffer, pH 7 / lipase PS / acetone / Ambient temperature
6: 87 percent / potassium phosphate buffer, pH 7 / porcine pancreatic lipase / acetone / 5 h
With
pyridine; sodium tetrahydroborate; potassium phosphate buffer; sodium hydrogencarbonate; lithium chloride;
porcine pancreatic lipase; Lipase PS;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetone;
DOI:10.1021/jo00036a013
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 61 percent / NaBH4, LiCl / tetrahydrofuran; methanol / 0.17 h
2: pyridine / CH2Cl2
3: potassium phosphate buffer, pH 7 / lipase PS / acetone / Ambient temperature
4: 87 percent / potassium phosphate buffer, pH 7 / porcine pancreatic lipase / acetone / 5 h
With
pyridine; sodium tetrahydroborate; potassium phosphate buffer; lithium chloride;
porcine pancreatic lipase; Lipase PS;
In
tetrahydrofuran; methanol; dichloromethane; acetone;
DOI:10.1021/jo00036a013
