5-bromo-N-ethyl-2-methoxynicotinamide

Base Information

• Chemical Name: 5-bromo-N-ethyl-2-methoxynicotinamide
• CAS No.: 1315544-54-7
• Molecular Formula: C₉H₁₁BrN₂O₂
• Molecular Weight: 259.103
• Mol file: 1315544-54-7.mol

Synonyms:

Chemical Property of 5-bromo-N-ethyl-2-methoxynicotinamide

Chemical Property:

Purity/Quality:

5-Bromo-N-ethyl-2-methoxynicotinamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-bromo-N-ethyl-2-methoxynicotinamide

There total 2 articles about 5-bromo-N-ethyl-2-methoxynicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

ethanamine hydrochloride (557-66-4) + 5-bromo-2-methoxy-nicotinic acid (54916-66-4) → 5-bromo-N-ethyl-2-methoxynicotinamide (1315544-54-7)

Guidance literature:

5-bromo-2-methoxy-nicotinic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 18h;

ethanamine hydrochloride; In dichloromethane; at 20 ℃; for 3h;

Reference yield: 64.0%

ethylamine hydrochloride + 5-bromo-2-methoxy-nicotinic acid (54916-66-4) → 5-bromo-N-ethyl-2-methoxynicotinamide (1315544-54-7)

Guidance literature:

5-bromo-2-methoxy-nicotinic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; for 18h;

ethylamine hydrochloride; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

5-bromo-N-ethyl-2-methoxynicotinamide (1315544-54-7) → (+/-)-N3-ethyl-N5-((trans)-2-methylcyclopropyl)-2-oxo-1-((1-tosyl-1H-indol-4-yl)methyl)-1,2-dihydropyridine-3,5-dicarboxamide

Guidance literature:

Multi-step reaction with 5 steps

1.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; triethylamine; palladium diacetate / 18 h / 20 - 110 °C / 5171.62 Torr / Inert atmosphere

2.1: water; lithium hydroxide / acetonitrile; tetrahydrofuran / 16 h / 20 °C

3.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

3.2: 16 h / 0 - 20 °C

4.1: sodium iodide; chloro-trimethyl-silane / acetonitrile / 1 h / 20 °C / Inert atmosphere

5.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 90 °C / Inert atmosphere

With chloro-trimethyl-silane; water; palladium diacetate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium iodide; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

ethanamine hydrochloride

5-bromo-2-methoxy-nicotinic acid