ara-CDP-rac-1-O-hexadecyl-2-O-palmitoylglycerol

Base Information

• Chemical Name: ara-CDP-rac-1-O-hexadecyl-2-O-palmitoylglycerol
• CAS No.: 105158-38-1
• Molecular Formula: C₄₄H₈₁N₃O₁₄P₂*2Na
• Molecular Weight: 984.066
• Mol file: 105158-38-1.mol

Synonyms:

Chemical Property of ara-CDP-rac-1-O-hexadecyl-2-O-palmitoylglycerol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ara-CDP-rac-1-O-hexadecyl-2-O-palmitoylglycerol

There total 8 articles about ara-CDP-rac-1-O-hexadecyl-2-O-palmitoylglycerol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

rac-1-hexadecyl-2-palmitoylglycero-3-phosphoric acid (103383-64-8) + 1-β-D-arabinofuranosylcytosine 5'-monophosphoromorpholidate 4-morpholine N,N'-dicyclohexylcarboxamidinium salt (69467-87-4) → ara-CDP-rac-1-O-hexadecyl-2-O-palmitoylglycerol (105158-38-1)

Guidance literature:

With pyridine; for 120h; Ambient temperature;

DOI:10.1021/jm00160a041

Reference yield:

rac-1-O-hexadecyl-3-O-benzylglycerol (103475-80-5) → ara-CDP-rac-1-O-hexadecyl-2-O-palmitoylglycerol (105158-38-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 99 percent / pyridine / benzene / 70 °C

2: H₂, HOAc / 10percent Pd/C / hexane / 72 h / 2585.7 Torr

3: 50.4 percent / POCl₃, Et₃N / hexane; toluene / 18 h / Ambient temperature

4: 30 percent / pyridine / 120 h / Ambient temperature

With pyridine; hydrogen; acetic acid; triethylamine; trichlorophosphate; palladium on activated charcoal; In hexane; toluene; benzene;

DOI:10.1021/jm00160a041

Reference yield:

Hexadecanoic acid 2-benzyloxy-1-hexadecyloxymethyl-ethyl ester (95895-49-1) → ara-CDP-rac-1-O-hexadecyl-2-O-palmitoylglycerol (105158-38-1)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂, HOAc / 10percent Pd/C / hexane / 72 h / 2585.7 Torr

2: 50.4 percent / POCl₃, Et₃N / hexane; toluene / 18 h / Ambient temperature

3: 30 percent / pyridine / 120 h / Ambient temperature

With pyridine; hydrogen; acetic acid; triethylamine; trichlorophosphate; palladium on activated charcoal; In hexane; toluene;

DOI:10.1021/jm00160a041

upstream raw materials:

rac-1-hexadecyl-2-palmitoylglycero-3-phosphoric acid

1-β-D-arabinofuranosylcytosine 5'-monophosphoromorpholidate 4-morpholine N,N'-dicyclohexylcarboxamidinium salt

3-(hexadecyloxy)-1,2-propanediol

1-O-hexadecyl-3-O-trityl-rac-glycerol

Refernces