Naltrexone 3-acetate

Base Information

Chemical Name:Naltrexone 3-acetate
CAS No.:111129-14-7
Molecular Formula:C₂₂H₂₅NO₅
Molecular Weight:383.444
Hs Code.:
DSSTox Substance ID:DTXSID00149509
Nikkaji Number:J458.263B
Wikidata:Q83015298

Synonyms:Naltrexone 3-acetate;111129-14-7;SCHEMBL12637941;DTXSID00149509;Morphinan-6-one, 3-(acetyloxy)-17-(cyclopropylmethyl)-4,5-epoxy-3-hydroxy-, (5alpha)-

Suppliers and Price of Naltrexone 3-acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 0 raw suppliers

Chemical Property of Naltrexone 3-acetate

Chemical Property:

Vapor Pressure:5.6E-14mmHg at 25°C
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:383.17327290
Heavy Atom Count:28
Complexity:722

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)OC1=C2C3=C(CC4C5(C3(CCN4CC6CC6)C(O2)C(=O)CC5)O)C=C1
Isomeric SMILES:CC(=O)OC1=C2C3=C(C[C@@H]4[C@]5([C@]3(CCN4CC6CC6)[C@@H](O2)C(=O)CC5)O)C=C1

Technology Process of Naltrexone 3-acetate

There total 4 articles about Naltrexone 3-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.3%

: 111129-14-7
3-O-acetylnaltrexone

Guidance literature:

Reference yield:

: 16676-29-2
naltrexone Hydrochloride

: 108-24-7
acetic anhydride

: 111129-14-7
3-O-acetylnaltrexone

Guidance literature:: With triethylamine; In ethyl acetate; at 40 ℃; for 2h;

Reference yield:

: 16590-41-3
Naltrexone

: 108-24-7
acetic anhydride

: 111129-14-7
3-O-acetylnaltrexone

Guidance literature:: Naltrexone; With sodium hydroxide; In water; toluene; at 21.5 - 22.6 ℃; for 0.416667h; Inert atmosphere;

acetic anhydride; In water; toluene; at 27.1 ℃; for 0.5h;

With sodium hydroxide; In water; toluene; for 0.166667h; pH=6.55 - 10.15; Product distribution / selectivity;