4-[(2-Fluoroethoxy)methyl]piperidine hydrochloride

Base Information

Chemical Name:4-[(2-Fluoroethoxy)methyl]piperidine hydrochloride
CAS No.:1220036-72-5
Molecular Formula:C₈H₁₆FNO*ClH
Molecular Weight:197.68
Hs Code.:
Mol file:1220036-72-5.mol

Synonyms:1220036-72-5;4-[(2-FLUOROETHOXY)METHYL]PIPERIDINE HYDROCHLORIDE;4-((2-Fluoroethoxy)methyl)piperidine hydrochloride;4-(2-fluoroethoxymethyl)piperidine;hydrochloride;AKOS006335616;SB42089;4-((2-Fluoroethoxy)methyl)piperidinehydrochloride

Suppliers and Price of 4-[(2-Fluoroethoxy)methyl]piperidine hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
4-[(2-Fluoroethoxy)methyl]piperidine hydrochloride
500mg
$ 237.00

Matrix Scientific
4-[(2-Fluoroethoxy)methyl]piperidine hydrochloride
2.500g
$ 720.00

Crysdot
4-((2-Fluoroethoxy)methyl)piperidinehydrochloride 95+%
5g
$ 499.00

Total 2 raw suppliers

Chemical Property of 4-[(2-Fluoroethoxy)methyl]piperidine hydrochloride

Chemical Property:

Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:197.0982700
Heavy Atom Count:12
Complexity:94.1

Purity/Quality:

98%min ^*data from raw suppliers

4-[(2-Fluoroethoxy)methyl]piperidine hydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CNCCC1COCCF.Cl

Technology Process of 4-[(2-Fluoroethoxy)methyl]piperidine hydrochloride

There total 4 articles about 4-[(2-Fluoroethoxy)methyl]piperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: tert-butyl 4-((2-fluoroethoxy)methyl)piperidine-1-carboxylate

: 1220036-72-5
1-4-((2-fluoroethoxy)methyl)piperidine hydrochloride

Guidance literature:: tert-butyl 4-((2-fluoroethoxy)methyl)piperidine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 22 ℃; for 4h; Inert atmosphere;

With hydrogenchloride; In methanol;
DOI:10.1016/j.ejmech.2021.113214

Reference yield:

: C₁₄H₂₅NO₅

: 1220036-72-5
1-4-((2-fluoroethoxy)methyl)piperidine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 22 °C / Inert atmosphere

2: pyridine-2-sulfonyl fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 69 h

3: trifluoroacetic acid / dichloromethane / 4 h / 22 °C / Inert atmosphere

With pyridine-2-sulfonyl fluoride; lithium aluminium tetrahydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.ejmech.2021.113214

Reference yield:

: 1260099-72-6
tert-butyl 4-((2-hydroxyethoxy)methyl)piperidine-1-carboxylate

: 1220036-72-5
1-4-((2-fluoroethoxy)methyl)piperidine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine-2-sulfonyl fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 69 h

2: trifluoroacetic acid / dichloromethane / 4 h / 22 °C / Inert atmosphere

With pyridine-2-sulfonyl fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In dichloromethane; toluene;
DOI:10.1016/j.ejmech.2021.113214