7-(chloromethyl)-[1,2,4]triazolo[1,5-a]pyridine

Base Information

• Chemical Name: 7-(chloromethyl)-[1,2,4]triazolo[1,5-a]pyridine
• CAS No.: 1313726-28-1
• Molecular Formula: C₇H₆ClN₃
• Molecular Weight: 167.598
• Mol file: 1313726-28-1.mol

Synonyms:

Chemical Property of 7-(chloromethyl)-[1,2,4]triazolo[1,5-a]pyridine

Chemical Property:

• Density: 1.42±0.1 g/cm3(Predicted)

Purity/Quality:

7-(Chloromethyl)-[1,2,4]triazolo[1,5-a]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-(chloromethyl)-[1,2,4]triazolo[1,5-a]pyridine

There total 3 articles about 7-(chloromethyl)-[1,2,4]triazolo[1,5-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

N-(4-(chloromethyl)pyridin-2-yl)-N'-hydroxyformimidamide → 7-(chloromethyl)-[1,2,4]triazolo[1,5-a]pyridine (1313726-28-1)

Guidance literature:

With trifluoroacetic acid; In tetrahydrofuran; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/jm500510f

Reference yield:

N-(4-(chloromethyl)pyridin-2-yl)-N'-hydroxyformimidamide (1313726-27-0) → 7-(chloromethyl)-[1,2,4]triazolo[1,5-a]pyridine (1313726-28-1)

Guidance literature:

N-(4-(chloromethyl)pyridin-2-yl)-N'-hydroxyformimidamide; With trifluoroacetic anhydride; In trifluoroacetic acid; at 0 - 20 ℃; for 3h; Inert atmosphere;

With sodium hydrogencarbonate; In water; pH=8;

Reference yield:

4-(chloromethyl)pyridin-2-amine (872706-97-3) → 7-(chloromethyl)-[1,2,4]triazolo[1,5-a]pyridine (1313726-28-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: isopropyl alcohol / 3 h / 90 °C / Inert atmosphere

1.2: 50 °C

2.1: trifluoroacetic anhydride / trifluoroacetic acid / 3 h / 0 - 20 °C / Inert atmosphere

2.2: pH 8

With trifluoroacetic anhydride; In isopropyl alcohol; trifluoroacetic acid;

upstream raw materials:

4-(chloromethyl)pyridin-2-amine

N-(4-(chloromethyl)pyridin-2-yl)-N'-hydroxyformimidamide

Refernces

• 1、 -. "CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR". . . Retrieved 2012/10/08.