872706-97-3

Usage

Uses

Used in Pharmaceutical Industry:
2-Pyridinamine,4-(chloromethyl)-(9CI) is utilized as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of compounds with potential therapeutic applications, contributing to the advancement of new medications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Pyridinamine,4-(chloromethyl)-(9CI) serves as an intermediate for the production of agrochemicals. Its reactivity and structural features are harnessed to create compounds that can be used in the development of pesticides and other agricultural products to enhance crop protection and yield.
Used in Organic Synthesis:
2-Pyridinamine,4-(chloromethyl)-(9CI) is also used as a versatile building block in organic synthesis. Its chloromethyl group facilitates the preparation of a range of functionalized pyridine derivatives, which can be further utilized in various industrial applications, including the creation of dyes, polymers, and other specialty chemicals.
It is crucial to handle 2-Pyridinamine,4-(chloromethyl)-(9CI) with care due to its potential hazards if not used properly, ensuring safety in its applications across different industries.

InChI:InChI=1/C6H7ClN2/c7-4-5-1-2-9-6(8)3-5/h1-3H,4H2,(H2,8,9)

Upstream product

• 53547-60-7 4-methyl-2-pyridinecarbaldehyde 
• 672324-82-2 tert-butyl 4-(chloromethyl)pyridin-2-ylcarbamate 
• 105250-17-7 2-amino-4-hydroxymethylpyridine 
• 1186663-31-9 4-(chloromethyl)pyridine-2-amine hydrochloride 

Downstream Products

• 872708-84-4 2-{[(2-aminopyridin-4-yl)methyl]amino}-N-(2,2-difluoro-1,3-benzodioxol-5-yl)benzamide 
• 105250-17-7 2-amino-4-hydroxymethylpyridine 
• 1313726-28-1 7-(chloromethyl)-[1,2,4]triazolo[1,5-a]pyridine 
• 872706-98-4 N-(4-(chloromethyl)pyridin-2-yl)acetamide 

Relevant academic research and scientific papers

Preparation method of 2-aminopyridine-4-methyl alcohol intermediate

The invention discloses a preparation method of a 2-aminopyridine-4-methyl alcohol intermediate. The preparation method includes the following steps of adopting 4-methylpyridine-2-formaldehyde as a raw material and making the raw material subjected to a chlorine substitute reaction to convert methyl into chloromethyl; then conducting an oxidizing reaction to convert formyl into carboxyl; then making the raw material react with triethylamine and DPPA to convert carboxyl into amino and oxidizing chloromethyl into hydroxymethyl to obtain 2-aminopyridine-4-methyl alcohol. The preparation method issimple in operation, mild in condition and high in product purity and product yield and generates few by-products.

SMALL MOLECULE INHIBITORS OF COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) AND USES THEREOF

Compounds of formula (I), which are useful as CSF-1R inhibitors, are provided. Also provided are pharmaceutical compositions and kits comprising said compounds, as well as methods and uses pertaining to said compounds.

1,3-THIAZOLE-5-CARBOXAMIDES USEFUL AS CANCER CHEMOTHERAPEUTIC AGENTS

This invention relates to novel 1, 3- thiazole-5 -carboxamide compounds of formula (I), pharmaceutical compositions containing such compounds, and the use of those compounds or compositions as cancer chemotherapeutic agents.

1-METHYL-1H-PYRAZOLE-4-CARBOXAMIDES USEFUL AS CANCER CHEMOTHERAPEUTIC AGENTS

This invention relates to novel 1 -Methyl- lH-pyrazole-4-carboxamide compounds, pharmaceutical compositions containing such compounds, and the use of those compounds or compositions as cancer chemotherapeutic agents.

2-AMINOARYLCARBOXAMIDES USEFUL AS CANCER CHEMOTHERAPEUTIC AGENTS

A compound having the formula (1) in which the ring containing E is a phenyl, a pyridine, or a pyrimidine. In formula (1) the symbol A represents (see structures) wherein the group R4 represents halogen, CF3, or H, provided that the maximum number of CF3 groups on any A is 2, and the maximum number of hydrogens on A is 2 for the A groups which together with the carbon atoms to which they are attached form 6-membered rings, and the maximum number of hydrogens on A is 1 for the A group which together with the carbon atoms to which it is attached forms a 5-membered ring. Z represents N or CH when E forms a phenyl ring, and represents CH when E forms a pyridine or pyrimidine. The groups R1, R2 and R3 and the subscripts a, b, and d are as defined in the text and claims. Pharmaceutical compositions containing a compound of formula (1) and methods of treating cancer using compounds of formula (1) are also disclosed and claimed.

2-AMINOTHIOPHENECARBOXAMIDES USEFUL AS CANCER CHEMOTHERAPEUTIC AGENTS

This invention relates to novel 2-aminothiophenecarboxamide compounds, pharmaceutical compositions containing such compounds, and the use of those compounds or compositions as cancer chemotherapeutic agents.