5-chloro-2-methoxy-3-acetylpyridine

Base Information

• Chemical Name: 5-chloro-2-methoxy-3-acetylpyridine
• CAS No.: 122433-46-9
• Molecular Formula: C₈H₈ClNO₂
• Molecular Weight: 185.61
• Mol file: 122433-46-9.mol

Synonyms:

Chemical Property of 5-chloro-2-methoxy-3-acetylpyridine

Chemical Property:

• Boiling Point: 278.5±40.0 °C(Predicted)
• Density: 1.236±0.06 g/cm3(Predicted)

Purity/Quality:

95% ^*data from raw suppliers

1-(5-Chloro-2-methoxy-pyridin-3-yl)-ethanone 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-chloro-2-methoxy-3-acetylpyridine

There total 3 articles about 5-chloro-2-methoxy-3-acetylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

3-(5-chloro-2-methoxy-3-pyridyl)-3-oxo-propionate (122433-45-8) → 5-chloro-2-methoxy-3-acetylpyridine (122433-46-9)

Guidance literature:

With sodium hydroxide; for 1h; Heating;

DOI:10.1021/jm00169a005

Reference yield:

2-methoxynicotinic acid (16498-81-0) → 5-chloro-2-methoxy-3-acetylpyridine (122433-46-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / NaOCl (Clorox) / Ambient temperature

2: 57 percent / tetrahydrofuran / 3 h / Heating

3: 65 percent / 1 N NaOH / 1 h / Heating

With sodium hydroxide; sodium hypochlorite; In tetrahydrofuran;

DOI:10.1021/jm00169a005

Reference yield:

5-chloro-2-methoxypyridine-3-carboxylic acid (54916-65-3) → 5-chloro-2-methoxy-3-acetylpyridine (122433-46-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 57 percent / tetrahydrofuran / 3 h / Heating

2: 65 percent / 1 N NaOH / 1 h / Heating

With sodium hydroxide; In tetrahydrofuran;

DOI:10.1021/jm00169a005

upstream raw materials:

3-(5-chloro-2-methoxy-3-pyridyl)-3-oxo-propionate

2-methoxynicotinic acid

5-chloro-2-methoxypyridine-3-carboxylic acid

Downstream raw materials:

6-chloro-2,3-dihydro-4H-pyrano<2,3-b>pyridin-4-one

Refernces

• 1、 -. "Azolidinedione derivatives". . . Retrieved 2008/06/13.