54916-65-3

Usage

Uses

Used in Pharmaceutical Industry:
5-Chloro-2-methoxynicotinic acid is used as a building block in the synthesis of various organic compounds for the development of new drugs. Its unique structure allows for the creation of novel pharmaceutical agents with potential therapeutic benefits.
Used in Agrochemical Industry:
In the agrochemical sector, 5-Chloro-2-methoxynicotinic acid is utilized in the development of new agrochemicals, potentially enhancing crop protection and yield through innovative chemical formulations.
Used in Materials Science:
5-Chloro-2-methoxynicotinic acid is used in the production of advanced materials, leveraging its chemical properties to contribute to the development of new materials with improved characteristics for various applications.
Used in Research and Development:
This chemical compound is also employed in research and development efforts, where its unique structure and properties are further explored to uncover additional uses and applications in diverse scientific and industrial fields.
As ongoing studies and applications of 5-Chloro-2-methoxynicotinic acid continue, its potential uses and properties are being further investigated, promising to expand its utility in multiple industries.

InChI:InChI=1/C7H6ClNO3/c1-12-6-5(7(10)11)2-4(8)3-9-6/h2-3H,1H3,(H,10,11)

Upstream product

• 2942-59-8 2-chloronicotinic acid 
• 16498-81-0 2-methoxynicotinic acid 

Downstream Products

• 82060-51-3 methyl 5-Chloro-2-methoxypyridine-3-carboxylate 
• 122433-46-9 5-chloro-2-methoxy-3-acetylpyridine 
• 122433-49-2 6-chloro-2,3-dihydro-4H-pyrano<2,3-b>pyridin-4-one 

Relevant academic research and scientific papers

Spiro hydantoin aldose reductase inhibitors derived from 8-aza-4-chromanones

A series of spiro hydantoins derived from 8-azachromanones (2,3-dihydro-4H-pyrano[2,3-b]pyridin-4-ones) has been prepared and tested for aldose reductase inhibitory activity. The standard Bucherer-Bergs conditions had to be drastically modified to increas

Azolidinedione derivatives

A series of novel spiro-deteroazolones derived from a 2,3-dihydropryrano[2,3-b]pyridine ring system have been prepared, including their pharmaceutically acceptable salts. These compounds are useful in therapy as aldose reductase inhibitors for the control of certain chronic diabetic complications. Typical member compounds include spiro-imides, spiro-oxazolidinediones, spiro-thiazolidinediones and spiro-imidazolidinediones derived from the aforesaid ring system. (4'S) (2'R)-6'-Chloro-2',3'-dihydro-2'-methyl-spiro-[imidazolidine-4,4'-4'H-pyrano[2,3-b]pyridine]-2,5-dione represents a typical and preferred member compound. Methods for preparing all these compounds from known starting materials are provided.

AN IMPROVED METHOD OF CHLORINATING 2-ALKOXYNICOTINIC ACIDS

A novel chlorination process for preparing 5-chloro-2-alkoxynicotinic acids has been developed using commercial 5.25percent sodium hypochlorite (Clorox) as a chlorinating agent.

Azolidinedione derivatives

Spiro-heteroazolones of formula wherein, Z is methylene, oxygen, sulfur or imino; Y is oxygen or sulfur; and -A=B-D=E- represents -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH or -CH=CH-CH=N-, or an N-oxide derivative thereof. These compounds are useful in therapy as aldose reductase inhibitors for the control of certain chronic diabetic complications. Typical member compounds include spiro-imides, spiro-oxa-zolidinediones, spiro-thiazolidinediones and spiro-imidazolidinediones derived from the aforesaid ring system. (4'S)(2'R)-6'-Chloro-2',3'-dihydro-2'-methyl--spiro-[imidazolidine-4,4'-4'H-pyrano[2,3-b]pyridine]--2,5-dione represents a typical and preferred member compound. Methods for preparing all these compounds from known starting materials are provided.

Chlorination of 2-methoxynicotinic acid

A novel process for chlorinating 2-methoxynicotinic acid at the 5-position of the molecule is disclosed. The process involves the use of an alkali metal hypochlorite as the chlorinating agent in a homogeneous aqueous solvent system. The compound so produced, 5-chloro-2-methoxynicotinic acid, is known to be useful as an intermediate leading to various oral hypoglycemic agents of the benzenesulfonylurea class.