Technology Process of ML67-33
There total 6 articles about ML67-33 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium azide; ammonium chloride;
In
N,N-dimethyl-formamide;
at 120 ℃;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: potassium carbonate / acetone / 2 h / Reflux
2: tetrahydrofuran; monoethylene glycol diethyl ether / 2 h / -78 - 20 °C
3: phosphoric acid / water / 2 h / 35 °C
4: N-benzyl-trimethylammonium hydroxide / 1 h / 20 °C
5: sulfuryl dichloride / dichloromethane / 0 °C / Darkness
6: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 120 °C / Inert atmosphere
With
sodium azide; sulfuryl dichloride; phosphoric acid; N-benzyl-trimethylammonium hydroxide; potassium carbonate; ammonium chloride;
In
tetrahydrofuran; dichloromethane; monoethylene glycol diethyl ether; water; N,N-dimethyl-formamide; acetone;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: tetrahydrofuran; monoethylene glycol diethyl ether / 2 h / -78 - 20 °C
2: phosphoric acid / water / 2 h / 35 °C
3: N-benzyl-trimethylammonium hydroxide / 1 h / 20 °C
4: sulfuryl dichloride / dichloromethane / 0 °C / Darkness
5: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 120 °C / Inert atmosphere
With
sodium azide; sulfuryl dichloride; phosphoric acid; N-benzyl-trimethylammonium hydroxide; ammonium chloride;
In
tetrahydrofuran; dichloromethane; monoethylene glycol diethyl ether; water; N,N-dimethyl-formamide;