(2R)-2-ISOPROPYL-4-OXOPYRROLIDINE, N-BOC PROTECTED

Base Information

• Chemical Name: (2R)-2-ISOPROPYL-4-OXOPYRROLIDINE, N-BOC PROTECTED
• CAS No.: 1217633-41-4
• Molecular Formula: C₁₂H₂₁NO₃
• Molecular Weight: 227.304
• Mol file: 1217633-41-4.mol

Synonyms:

Chemical Property of (2R)-2-ISOPROPYL-4-OXOPYRROLIDINE, N-BOC PROTECTED

Chemical Property:

Purity/Quality:

tert-Butyl (2R)-2-isopropyl-4-oxopyrrolidine-1-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of (2R)-2-ISOPROPYL-4-OXOPYRROLIDINE, N-BOC PROTECTED

There total 10 articles about (2R)-2-ISOPROPYL-4-OXOPYRROLIDINE, N-BOC PROTECTED which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-4-hydroxyproline methyl ester hydrochloride (40216-83-9) → tert-butyl (2S)-4-oxo-2-(propan-2-yl)pyrrolidine-1-carboxylate (1212437-79-0,1217633-41-4)

Guidance literature:

Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 20 °C / Large scale

1.2: 0 - 20 °C / Large scale

2.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

3.1: magnesium / diethyl ether / 30 °C / Reflux

3.2: 4 h / 0 - 20 °C

4.1: triethylamine / toluene / 0.17 h / -78 °C

4.2: 3.5 h / -78 °C

5.1: hydrogen / methanol / 3 h / 60 °C / 30402 Torr

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 0 - 20 °C

7.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / -78 °C

7.2: -78 °C

With 1H-imidazole; oxalyl dichloride; tetrabutyl ammonium fluoride; hydrogen; magnesium; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

tert-butyl (2S,4R)-4-hydroxy-2-(propan-2-yl)pyrrolidine-1-carboxylate (927893-02-5) → tert-butyl (2S)-4-oxo-2-(propan-2-yl)pyrrolidine-1-carboxylate (1212437-79-0,1217633-41-4)

Guidance literature:

tert-butyl (2S,4R)-4-hydroxy-2-(propan-2-yl)pyrrolidine-1-carboxylate; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃;

With triethylamine; In dichloromethane; at -78 ℃;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl (2S)-4-oxo-2-(propan-2-yl)pyrrolidine-1-carboxylate (1212437-79-0,1217633-41-4)

Guidance literature:

Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 20 °C / Large scale

1.2: 0 - 20 °C / Large scale

2.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

3.1: magnesium / diethyl ether / 30 °C / Reflux

3.2: 4 h / 0 - 20 °C

4.1: triethylamine / toluene / 0.17 h / -78 °C

4.2: 3.5 h / -78 °C

5.1: hydrogen / methanol / 3 h / 60 °C / 30402 Torr

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 0 - 20 °C

7.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / -78 °C

7.2: -78 °C

With 1H-imidazole; oxalyl dichloride; tetrabutyl ammonium fluoride; hydrogen; magnesium; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;

upstream raw materials:

di-tert-butyl dicarbonate

4R-4-hydroxyproline

(R)-4-hydroxy-L-proline ethyl ester

1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate

Refernces