3,4-dichloro-α-<<(1,1-dimethylethoxy)carbonyl>amino>-benzeneacetic acid

Base Information

• Chemical Name: 3,4-dichloro-α-<<(1,1-dimethylethoxy)carbonyl>amino>-benzeneacetic acid
• CAS No.: 1241683-86-2
• Molecular Formula: C₁₃H₁₅Cl₂NO₄
• Molecular Weight: 320.172
• Mol file: 1241683-86-2.mol

Synonyms:

Chemical Property of 3,4-dichloro-α-<<(1,1-dimethylethoxy)carbonyl>amino>-benzeneacetic acid

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

(R)-2-((tert-Butoxycarbonyl)amino)-2-(3,4-dichlorophenyl)aceticacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4-dichloro-α-<<(1,1-dimethylethoxy)carbonyl>amino>-benzeneacetic acid

There total 3 articles about 3,4-dichloro-α-<<(1,1-dimethylethoxy)carbonyl>amino>-benzeneacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

di-tert-butyl dicarbonate (24424-99-5) + α-amino-3,4-dichloro-phenylacetic acid (128349-50-8) → 3,4-dichloro-α-<<(1,1-dimethylethoxy)carbonyl>amino>-benzeneacetic acid (142121-95-7,1241683-86-2)

Guidance literature:

With sodium hydroxide; In tert-butyl alcohol; for 24h; Ambient temperature;

DOI:10.1021/jm00055a002

Reference yield:

(3,4-dichlorophenyl)hydroxyiminoacetic acid (146621-85-4) → 3,4-dichloro-α-<<(1,1-dimethylethoxy)carbonyl>amino>-benzeneacetic acid (142121-95-7,1241683-86-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 57 percent / H₂, conc aq. HCl / 5percent Pd/C / ethanol / 6 h / 760 Torr / Ambient temperature

2: 48 percent / 2N aq. NaOH / 2-methyl-propan-2-ol / 24 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; hydrogen; palladium on activated charcoal; In ethanol; tert-butyl alcohol;

DOI:10.1021/jm00055a002

Reference yield:

3,4-dichloro-benzeneacetonitrile (3218-49-3) → 3,4-dichloro-α-<<(1,1-dimethylethoxy)carbonyl>amino>-benzeneacetic acid (142121-95-7,1241683-86-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / isobutyl nitrite, aq. KOH / methanol / 26 h / 50 - 90 °C

2: 57 percent / H₂, conc aq. HCl / 5percent Pd/C / ethanol / 6 h / 760 Torr / Ambient temperature

3: 48 percent / 2N aq. NaOH / 2-methyl-propan-2-ol / 24 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; sodium hydroxide; nitrous acid isobutyl ester; hydrogen; palladium on activated charcoal; In methanol; ethanol; tert-butyl alcohol;

DOI:10.1021/jm00055a002

upstream raw materials:

di-tert-butyl dicarbonate

α-amino-3,4-dichloro-phenylacetic acid

(3,4-dichlorophenyl)hydroxyiminoacetic acid

3,4-dichloro-benzeneacetonitrile