128349-50-8

Usage

Uses

Used in Pharmaceutical Industry:
AMINO-(3,4-DICHLORO-PHENYL)-ACETIC ACID is used as a key intermediate in the synthesis of various pharmaceuticals for its antimicrobial, antifungal, and other biological properties. It contributes to the development of drugs that target a wide range of infections and diseases.
Used in Agrochemical Industry:
In the agrochemical industry, AMINO-(3,4-DICHLORO-PHENYL)-ACETIC ACID is utilized as a component in the formulation of herbicides and other crop protection products. Its herbicidal properties help control and manage unwanted plant growth, ensuring healthier and more productive crops.
Used in Dye and Pigment Production:
AMINO-(3,4-DICHLORO-PHENYL)-ACETIC ACID serves as an intermediate in the production of dyes and pigments, contributing to the creation of a diverse range of colorants used in various industries, such as textiles, plastics, and printing inks.

InChI:InChI=1/C8H7Cl2NO2/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7H,11H2,(H,12,13)

Upstream product

• 146621-85-4 (3,4-dichlorophenyl)hydroxyiminoacetic acid 
• 143-33-9 sodium cyanide 
• 6287-38-3 3,4-dichlorobenzaldehyde 
• 7153-28-8 5-(3,4-dichloro-phenyl)-imidazolidine-2,4-dione 
• 3218-49-3 3,4-dichloro-benzeneacetonitrile 

Downstream Products

• 142121-95-7 3,4-dichloro-α-<<(1,1-dimethylethoxy)carbonyl>amino>-benzeneacetic acid 
• 1062130-83-9 C₃₂H₄₀Cl₂N₆O₇ 
• 1278598-08-5 tert-butyl N-(4-chlorobenzylidene)-2-(3,4-dichlorophenyl)glycinate 

Relevant academic research and scientific papers

Asymmetric synthesis of an antagonist of neurokinin receptors: SSR 241586

SSR 241586 is a 2,2-disubstituted morpholine, developed by Sanofi-Aventis, which is active in the treatment of schizophrenia and irritable bowel syndrome (IBS). Different strategies have been studied to synthesize this molecule and among the strategies an

Highly selective tripeptide thrombin inhibitors

Tripeptide aldehydes such as Boc-D-Phe-Pro-Arg-H (5l) exhibit potent direct inhibition of thrombin. This distinction offers important insight for the design of more potent and selective serine protease inhibitors which may be useful pharmacological tools and hold promise for development of clinically useful agents. The structure-activity relationships (SAR) on a series of anticoagulant peptides with high selectivity for the enzyme thrombin are discussed. The SAR is centered on a series of di- and tripeptide arginine aldehydes based on the structure of 5l. The structural and conformational role of the amino acid residue in position 1 was investigated by substitution with conformationally restricted aromatic amino acids, aromatic acids, and a dipeptide isostere containing the ψ[CH2N] amide bond replacement. Many of these peptides demonstrate potent antithrombotic activity along with selectivity toward thrombin, determined by comparison of in vitro inhibitory effects on trypsin, plasmin, factor Xa, and tissue plasminogen activator. Compound 5f, D-1-Tiq-Pro-Arg-H · sulfate is highly active and the most selective tripeptide aldehyde inhibitor of thrombin reported to date.

1-Aryl-N2-alkyl-ethanediamines as isosters of adrenergic arylethanolamines.

A family of 1-aryl-N2-alkyl-ethanediamines 1 isosteric with the N-alkyl-arylethanolamines are described. Although the prepared compounds were generally less potent than the N-alkyl-arylethanolamines, the 1-aryl-N'-(phenylmethyl)-N-alkyl-1,2-ethanediamines derivatives 6, are more active than the debenzylated free amino analogs 1, which may be indicative of the importance of the lipophilicity of the substituent at the alpha position to the aromatic ring.