di-tert-butyl 3-methyl hexahydropyridazine-1,2,3-tricarboxylate

Base Information

• Chemical Name: di-tert-butyl 3-methyl hexahydropyridazine-1,2,3-tricarboxylate
• CAS No.: 1161001-03-1
• Molecular Formula: C₁₆H₂₈N₂O₆
• Molecular Weight: 344.408

Synonyms:

Chemical Property of di-tert-butyl 3-methyl hexahydropyridazine-1,2,3-tricarboxylate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Tetrahydro-pyridazine-1,2,3-tricarboxylicacid1,2-di-tert-butylester3-methylester 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of di-tert-butyl 3-methyl hexahydropyridazine-1,2,3-tricarboxylate

There total 7 articles about di-tert-butyl 3-methyl hexahydropyridazine-1,2,3-tricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

di-tert-butyl 3-methyl-1,2,3,6-tetrahydropyridazine-1,2,3-tricarboxylate (1161000-95-8) → di-tert-butyl 3-methyl hexahydropyridazine-1,2,3-tricarboxylate (1161001-03-1,174497-80-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; under 760.051 - 3800.26 Torr;

DOI:10.3987/COM-08-S(D)31

Reference yield:

C17H32N2O9S (1397582-66-9) → di-tert-butyl 3-methyl hexahydropyridazine-1,2,3-tricarboxylate (1161001-03-1,174497-80-4)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.tet.2012.07.014

Reference yield:

2-(N,N'-di-tert-butoxycarbonylhydrazino)pent-4-enoic acid methyl ester (1397581-25-7) → di-tert-butyl 3-methyl hexahydropyridazine-1,2,3-tricarboxylate (1161001-03-1,174497-80-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

1.2: 1 h / 0 °C / Inert atmosphere

2.1: dmap; triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

With dmap; dimethylsulfide borane complex; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tet.2012.07.014

upstream raw materials:

di-tert-butyl 3-methyl-1,2,3,6-tetrahydropyridazine-1,2,3-tricarboxylate

2-(N,N'-di-tert-butoxycarbonylhydrazino)pent-4-enoic acid methyl ester

2-(N,N'-di-tert-butoxycarbonylhydrazino)-5-hydroxypentanoic acid methyl ester

C₁₇H₃₂N₂O₉S

Downstream raw materials:

N,N'-di-tert-butoxycarbonylpiperazic acid

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