N,N'-di-tert-butoxycarbonylpiperazic acid

Base Information

• Chemical Name: N,N'-di-tert-butoxycarbonylpiperazic acid
• CAS No.: 1219380-72-9
• Molecular Formula: C₁₅H₂₆N₂O₆
• Molecular Weight: 330.381
• Mol file: 1219380-72-9.mol

Synonyms:N,N'-di-tert-butoxycarbonylpiperazic acid

Chemical Property of N,N'-di-tert-butoxycarbonylpiperazic acid

Chemical Property:

• Boiling Point: 422.0±55.0 °C(Predicted)
• Density: 1.200±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N'-di-tert-butoxycarbonylpiperazic acid

There total 3 articles about N,N'-di-tert-butoxycarbonylpiperazic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl 3-methyl hexahydropyridazine-1,2,3-tricarboxylate (1161001-03-1,174497-80-4) → N,N'-di-tert-butoxycarbonylpiperazic acid (1219380-72-9)

Guidance literature:

di-tert-butyl 3-methyl hexahydropyridazine-1,2,3-tricarboxylate; With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 6h; Inert atmosphere;

With hydrogenchloride; In water; Inert atmosphere;

DOI:10.1016/j.tet.2012.07.014

Reference yield:

N,N'-di-tert-butoxycarbonylpiperazic acid ethyl ester (336817-83-5) → N,N'-di-tert-butoxycarbonylpiperazic acid (1219380-72-9)

Guidance literature:

N,N'-di-tert-butoxycarbonylpiperazic acid ethyl ester; With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 6h; Inert atmosphere;

With hydrogenchloride; In water; Inert atmosphere;

DOI:10.1016/j.tet.2012.07.014

Reference yield:

1,2-di-tert-butyl 3,3-dibenzyl hexahydropyridazine-1,2,3,3-tetracarboxylate (1618700-88-1) → N,N'-di-tert-butoxycarbonylpiperazic acid (1219380-72-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 4h; under 760.051 Torr;

DOI:10.1080/00397911.2014.905601

upstream raw materials:

di-tert-butyl 3-methyl hexahydropyridazine-1,2,3-tricarboxylate

N,N'-di-tert-butoxycarbonylpiperazic acid ethyl ester

1,2-di-tert-butyl 3,3-dibenzyl hexahydropyridazine-1,2,3,3-tetracarboxylate

Downstream raw materials:

(3RS)-piperazic acid

3-(2-(tert-butoxycarbonylamino)-3-phenylpropyl) 1,2-di-tert-butyl hexahydropyridazine-1,2,3-tricarboxylate

3-(2-(tert-butoxycarbonylamino)-3-phenylpropyl) 1,2-di-tert-butyl hexahydropyridazine-1,2,3-tricarboxylate

(S)-di-tert-butyl 3-((S)-1-methoxy-1-oxo-3-phenylpropan-2-ylcarbamoyl)hexahydropyridazine-1,2-dicarboxylate

Refernces

• 1、 Duttagupta, Indranil,Goswami, Koushik,Sinha, Surajit. "Synthesis of cyclic α-hydrazino acids". experimental part. p. 8347 - 8357. Retrieved 2012/09/21.