N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide

Base Information

Chemical Name:N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
CAS No.:118290-26-9
Molecular Formula:C₂₇H₃₈N₆O₂
Molecular Weight:478.638
Hs Code.:
Mol file:118290-26-9.mol

Synonyms:

Suppliers and Price of N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
AF-DX384
25mg
$ 220.00

Sigma-Aldrich
AF-DX 384 Free Base ≥98% (HPLC)
25mg
$ 344.00

Sigma-Aldrich
AF-DX 384 Free Base ≥98% (HPLC)
5mg
$ 87.50

Cayman Chemical
AF-DX 384 ≥95%
10mg
$ 104.00

Cayman Chemical
AF-DX 384 ≥95%
5mg
$ 72.00

Cayman Chemical
AF-DX 384 ≥95%
1mg
$ 26.00

Cayman Chemical
AF-DX 384 ≥95%
25mg
$ 228.00

ApexBio Technology
AF-DX384
50mg
$ 959.00

ApexBio Technology
AF-DX384
10mg
$ 234.00

Total 7 raw suppliers

Chemical Property of N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide

Chemical Property:

Boiling Point:618.4±55.0 °C(Predicted)
PKA:11.55±0.20(Predicted)
Density:1.144±0.06 g/cm3(Predicted)
Storage Temp.:room temp
Solubility.:DMSO: soluble10mg/mL, clear (warmed)

Purity/Quality:

≥98% by HPLC ^*data from raw suppliers

AF-DX384 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description AF-DX 384 is an antagonist of M2 and M4 muscarinic acetylcholine receptors (Kis = 6.03 and 10 nM, respectively). It is selective for M2 and M4 over M1, M3, and M5 receptors (Kis = 30.9, 66.07, and 537.03 nM, respectively). AF-DX 384 increases acetylcholine release in the hippocampus and cortex of young and aged rats in vivo when infused locally at a concentration of 1 μM and in the cortex when administered intraperitoneally at a dose of 5 mg/kg. It reverses deficits in novel object recognition and passive avoidance in aged rats, as well as in young rats with impairments induced by scopolamine .

Technology Process of N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide

There total 36 articles about N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 87571-90-2
11-(chlorocarbonyl)-5,11-dihydro-6h-pyrido[2,3-b][1,4]benzodiazepin-6-one

: 118289-11-5
(+/-)-2-[2-(N',N'-dipropylaminomethyl)piperidin-1-yl]-ethan-1-amine

: 118290-26-9
AF-DX 384

Guidance literature:

Reference yield:

: 4377-33-7
2-chloromethylpyridine

: 118290-26-9
AF-DX 384

Guidance literature:: Multi-step reaction with 5 steps

1: 62 percent / Et₃N / ethanol / 48 h / 80 °C

2: 63 percent / H₂ / PtO₂ / acetic acid / 22 h / 2625.2 Torr / Ambient temperature

3: 62 percent / H₂O / 1 h / 0 °C

4: 55 percent / LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

5: 72 percent / acetonitrile / 1.) 50 deg C, 3 h, 2.) r.t., overnight

With lithium aluminium tetrahydride; hydrogen; triethylamine; platinum(IV) oxide; In tetrahydrofuran; ethanol; water; acetic acid; acetonitrile;
DOI:10.1039/p19960002925

Reference yield:

: 142-84-7
di-n-propylamine

: 118290-26-9
AF-DX 384

Guidance literature:: Multi-step reaction with 5 steps

1: 62 percent / Et₃N / ethanol / 48 h / 80 °C

2: 63 percent / H₂ / PtO₂ / acetic acid / 22 h / 2625.2 Torr / Ambient temperature

3: 62 percent / H₂O / 1 h / 0 °C

4: 55 percent / LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

5: 72 percent / acetonitrile / 1.) 50 deg C, 3 h, 2.) r.t., overnight

With lithium aluminium tetrahydride; hydrogen; triethylamine; platinum(IV) oxide; In tetrahydrofuran; ethanol; water; acetic acid; acetonitrile;
DOI:10.1039/p19960002925