tert-butyl 4-[(5-bromo-2-thienyl)carbonyl]tetrahydro-1(2H)-pyrazinecarboxylate

Base Information

• Chemical Name: tert-butyl 4-[(5-bromo-2-thienyl)carbonyl]tetrahydro-1(2H)-pyrazinecarboxylate
• CAS No.: 1017782-71-6
• Molecular Formula: C₁₄H₁₉BrN₂O₃S
• Molecular Weight: 375.286
• Mol file: 1017782-71-6.mol

Synonyms:

Chemical Property of tert-butyl 4-[(5-bromo-2-thienyl)carbonyl]tetrahydro-1(2H)-pyrazinecarboxylate

Chemical Property:

• Melting Point: 107-108°

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-[(5-Bromo-2-thienyl)carbonyl]tetrahydro-1(2H)-pyrazinecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-[(5-bromo-2-thienyl)carbonyl]tetrahydro-1(2H)-pyrazinecarboxylate

There total 1 articles about tert-butyl 4-[(5-bromo-2-thienyl)carbonyl]tetrahydro-1(2H)-pyrazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

5-bromothiophene-2-carboxylic acid (7311-63-9) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(5-bromothiophene-2-carbonyl)piperazine-1-carboxylate (1017782-71-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1021/acs.jmedchem.8b00168

Reference yield:

tert-butyl 4-(5-bromothiophene-2-carbonyl)piperazine-1-carboxylate (1017782-71-6) → 3-(5-(4-(tert-butoxycarbonyl)piperazine-1-carbonyl)thiophen-2-yl)-5-(4-(4-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-1-yl)benzoic acid

Guidance literature:

Multi-step reaction with 2 steps

1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate / water; 1,2-dimethoxyethane / 50 °C

2: potassium hydroxide / water; methanol / 15 h / 50 °C

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate; potassium hydroxide; In methanol; 1,2-dimethoxyethane; water; 1: |Suzuki Coupling;

DOI:10.1021/acs.jmedchem.8b00168

Reference yield:

tert-butyl 4-(5-bromothiophene-2-carbonyl)piperazine-1-carboxylate (1017782-71-6) → 3-(5-(piperazine-1-carbonyl)thiophen-2-yl)-5-(4-(4-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-1-yl)benzoic acid

Guidance literature:

Multi-step reaction with 3 steps

1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate / water; 1,2-dimethoxyethane / 50 °C

2: potassium hydroxide / water; methanol / 15 h / 50 °C

3: trifluoroacetic acid / 0.17 h / 20 °C

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate; trifluoroacetic acid; potassium hydroxide; In methanol; 1,2-dimethoxyethane; water; 1: |Suzuki Coupling;

DOI:10.1021/acs.jmedchem.8b00168

upstream raw materials:

5-bromothiophene-2-carboxylic acid

1-t-Butoxycarbonylpiperazine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1017782-71-6 tert-butyl 4-[(5-bromo-2-thienyl)carbonyl]tetrahydro-1(2H)-pyrazinecarboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send