(R)-2,2'-Bis(diphenylphosphino)-4,4',6,6'-tetraMethoxybiphenyl, 97+%

Base Information

• Chemical Name: (R)-2,2'-Bis(diphenylphosphino)-4,4',6,6'-tetraMethoxybiphenyl, 97+%
• CAS No.: 1365531-75-4
• Molecular Formula: C₄₀H₃₆O₄P₂
• Molecular Weight: 642.671
• Mol file: 1365531-75-4.mol

Synonyms:

Chemical Property of (R)-2,2'-Bis(diphenylphosphino)-4,4',6,6'-tetraMethoxybiphenyl, 97+%

Chemical Property:

• Boiling Point: 708.1±60.0 °C(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: air sensitive

Purity/Quality:

98% ^*data from raw suppliers

(R)-2,2'-Bis(diphenylphosphino)-4,4',6,6'-tetramethoxy)-1,1'-biphenyl, min. 97% (R)-Ph-Garphos(TM) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-2,2'-Bis(diphenylphosphino)-4,4',6,6'-tetraMethoxybiphenyl, 97+%

There total 14 articles about (R)-2,2'-Bis(diphenylphosphino)-4,4',6,6'-tetraMethoxybiphenyl, 97+% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(R)-(4,4′,6,6′-tetramethoxybiphenyl-2,2′-diyl)bis(diphenylphosphine oxide) → (R)-4,4′,6,6′-tetramethoxybiphenyl-2,2′-diyl-bis(diphenylphosphine) (1365531-75-4)

Guidance literature:

With trichlorosilane; In toluene; for 20h; Inert atmosphere; Reflux;

Reference yield:

(S)-(4,4′,6,6′-tetramethoxybiphenyl-2,2′-diyl)bis(diphenylphosphine oxide) → (S)-4,4′,6,6′-tetramethoxybiphenyl-2,2′-diyl-bis(diphenylphosphine) (1365531-75-4)

Guidance literature:

(S)-(4,4′,6,6′-tetramethoxybiphenyl-2,2′-diyl)bis(diphenylphosphine oxide); With trichlorosilane; In toluene; for 20h; Reflux; Inert atmosphere;

With sodium hydroxide; at 50 ℃; for 0.5h; Inert atmosphere;

DOI:10.1016/j.ica.2020.119850

Reference yield:

(2-bromo-3,5-dimethoxyphenyl)diphenylphosphine oxide (1365320-10-0) → (R)-4,4′,6,6′-tetramethoxybiphenyl-2,2′-diyl-bis(diphenylphosphine) (1365531-75-4)

Guidance literature:

Multi-step reaction with 3 steps

1: copper; iodine / N,N-dimethyl-formamide / 2 h / 140 °C

2: O,O'-dibenzoyl-L-tartaric acid / dichloromethane; diethyl ether / 0.5 h / 20 °C

3: trichlorosilane / toluene / 20 h / Inert atmosphere; Reflux

With trichlorosilane; iodine; copper; O,O'-dibenzoyl-L-tartaric acid; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;

upstream raw materials:

(R,S)-(4,4′,6,6′-tetramethoxybiphenyl-2,2′-diyl)bis(diphenylphosphine oxide)

1-bromo-3,5-dimethoxybenzene

chloro-diphenylphosphine

(3,5-dimethoxyphenyl)diphenylphosphine oxide

Refernces

• 1、 -. "BIARYL DIPHOSPHINE LIGANDS, INTERMEDIATES OF THE SAME AND THEIR USE IN ASYMMETRIC CATALYSIS". Page/Page column 31. . Retrieved 2012/03/27.