1-(difluoromethyl)cyclopropanecarboxylic acid

Base Information

• Chemical Name: 1-(difluoromethyl)cyclopropanecarboxylic acid
• CAS No.: 1314397-71-1
• Molecular Formula: C₅H₆F₂O₂
• Molecular Weight: 136.098
• Mol file: 1314397-71-1.mol

Synonyms:

Chemical Property of 1-(difluoromethyl)cyclopropanecarboxylic acid

Chemical Property:

• Boiling Point: 198.8±15.0 °C(Predicted)
• PKA: 3.41±0.20(Predicted)
• Density: 1.449±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

1-(difluoromethyl)cyclopropane-1-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(difluoromethyl)cyclopropanecarboxylic acid

There total 3 articles about 1-(difluoromethyl)cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.2%

1-difluoromethyl-cyclopropanecarboxylic acid ethyl ester (1267856-62-1) → 1-(difluoromethyl)cyclopropane-1-carboxylic acid (1314397-71-1)

Guidance literature:

With methanol; potassium hydroxide; In methanol; at 0 - 20 ℃; for 12h;

Reference yield:

ethyl 1-(hydroxymethyl)cyclopropanecarboxylate (3697-68-5) → 1-(difluoromethyl)cyclopropane-1-carboxylic acid (1314397-71-1)

Guidance literature:

Multi-step reaction with 3 steps

1: trichloroisocyanuric acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 1 h / -5 °C

2: diethylamino-sulfur trifluoride / dichloromethane / 12 h / 0 - 20 °C

3: potassium hydroxide; methanol / methanol / 12 h / 0 - 20 °C

With methanol; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; diethylamino-sulfur trifluoride; trichloroisocyanuric acid; potassium hydroxide; In methanol; dichloromethane;

Reference yield:

ethyl 1-formylcyclopropane-1-carboxylate (33329-70-3) → 1-(difluoromethyl)cyclopropane-1-carboxylic acid (1314397-71-1)

Guidance literature:

Multi-step reaction with 2 steps

1: diethylamino-sulfur trifluoride / dichloromethane / 12 h / 0 - 20 °C

2: potassium hydroxide; methanol / methanol / 12 h / 0 - 20 °C

With methanol; diethylamino-sulfur trifluoride; potassium hydroxide; In methanol; dichloromethane;

upstream raw materials:

ethyl 1-(hydroxymethyl)cyclopropanecarboxylate

ethyl 1-formylcyclopropane-1-carboxylate

1-difluoromethyl-cyclopropanecarboxylic acid ethyl ester

Refernces