Loxoprofen Ring-opening IMpurity

Base Information

Chemical Name:Loxoprofen Ring-opening IMpurity
CAS No.:1091621-61-2
Molecular Formula:C₁₅H₁₈O₅
Molecular Weight:278.305
Hs Code.:

Synonyms:

Suppliers and Price of Loxoprofen Ring-opening IMpurity

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-(1-Carboxyethyl)-δ-oxo-benzenehexanoicAcid
10mg
$ 1925.00

TRC
4-(1-Carboxyethyl)-δ-oxo-benzenehexanoicAcid
1mg
$ 250.00

Total 10 raw suppliers

Chemical Property of Loxoprofen Ring-opening IMpurity

Chemical Property:

Boiling Point:504.8±35.0 °C(Predicted)
PKA:4.32±0.10(Predicted)
Density:1.238±0.06 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

4-(1-Carboxyethyl)-δ-oxo-benzenehexanoicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 4-(1-Carboxyethyl)-δ-oxo-benzenehexanoic Acid is a degradation product of Loxoprofen (L472900, Na salt), a non-selective nonsteroidal anti-inflammatory drug (NSAID) that has been effective in reducing atherosclerosis in mice by reducing inflammation. It becomes active after metabolism in the body and inhibits the activation of cyclooxygenase.

Technology Process of Loxoprofen Ring-opening IMpurity

There total 3 articles about Loxoprofen Ring-opening IMpurity which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: C₁₅H₁₆O₃

: 1091621-61-2
6-(4-(1-carboxyethyl)phenyl)-5-oxohexanoic acid

Guidance literature:: With dihydrogen peroxide; sodium hydroxide; In ethanol; at 0 - 30 ℃; for 4h; Temperature; Reagent/catalyst;

Reference yield:

: 80530-55-8
2-[(p-chloromethyl)phenyl]propionic acid

: 1091621-61-2
6-(4-(1-carboxyethyl)phenyl)-5-oxohexanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hexamethylenetetramine / chloroform / 6 h / 63 - 65 °C

1.2: 2 h / Reflux

2.1: toluene / 6 h / 115 °C

3.1: dihydrogen peroxide; sodium hydroxide / ethanol / 4 h / 0 - 30 °C

With hexamethylenetetramine; dihydrogen peroxide; sodium hydroxide; In ethanol; chloroform; toluene;

Reference yield:

: 111128-12-2
2-[4-(bromomethyl)phenyl]propanoic acid

: 1091621-61-2
6-(4-(1-carboxyethyl)phenyl)-5-oxohexanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hexamethylenetetramine / chloroform / 6 h / 63 - 65 °C

1.2: 2 h / Reflux

2.1: toluene / 6 h / 115 °C

3.1: dihydrogen peroxide; sodium hydroxide / ethanol / 4 h / 0 - 30 °C

With hexamethylenetetramine; dihydrogen peroxide; sodium hydroxide; In ethanol; chloroform; toluene;