1-(4-Bromophenyl)-3-(piperidin-4-yl)ureahydrochloride

Base Information

• Chemical Name: 1-(4-Bromophenyl)-3-(piperidin-4-yl)ureahydrochloride
• CAS No.: 1233955-50-4
• Molecular Formula: C₁₂H₁₆BrN₃O*ClH
• Molecular Weight: 334.643
• Mol file: 1233955-50-4.mol

Synonyms:

Chemical Property of 1-(4-Bromophenyl)-3-(piperidin-4-yl)ureahydrochloride

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

1-(4-Bromophenyl)-3-(piperidin-4-yl)ureahydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-Bromophenyl)-3-(piperidin-4-yl)ureahydrochloride

There total 3 articles about 1-(4-Bromophenyl)-3-(piperidin-4-yl)ureahydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-(3-(4-bromophenyl)ureido)piperidine-1-carboxylate (1056676-31-3) → C12H16BrN3O*ClH (1233955-50-4)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃;

DOI:10.1021/acs.jmedchem.7b01051

Reference yield:

1-(tert-butoxycarbonyl)-4-aminopiperidine (87120-72-7) → C12H16BrN3O*ClH (1233955-50-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / toluene / 0.67 h / 0 - 20 °C

1.2: 20 °C

2.1: hydrogenchloride / ethyl acetate / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In ethyl acetate; toluene;

DOI:10.1021/acs.jmedchem.7b01051

Reference yield:

4-bromo-aniline (106-40-1) → C12H16BrN3O*ClH (1233955-50-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / toluene / 0.67 h / 0 - 20 °C

1.2: 20 °C

2.1: hydrogenchloride / ethyl acetate / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In ethyl acetate; toluene;

DOI:10.1021/acs.jmedchem.7b01051

upstream raw materials:

1-(tert-butoxycarbonyl)-4-aminopiperidine

tert-butyl 4-(3-(4-bromophenyl)ureido)piperidine-1-carboxylate

4-bromo-aniline