1,5-Anhydro-2,3-dideoxy-2-(methoxycarbonyl)-threopentitol

Base Information

• Chemical Name: 1,5-Anhydro-2,3-dideoxy-2-(methoxycarbonyl)-threopentitol
• CAS No.: 1048962-94-2
• Molecular Formula: C₇H₁₂O₄
• Molecular Weight: 160.17
• Mol file: 1048962-94-2.mol

Synonyms:

Chemical Property of 1,5-Anhydro-2,3-dideoxy-2-(methoxycarbonyl)-threopentitol

Chemical Property:

• Boiling Point: 252℃
• PKA: 14.09±0.40(Predicted)
• Flash Point: 101℃
• Density: 1.212

Purity/Quality:

99% ^*data from raw suppliers

1,5-Anhydro-2,3-dideoxy-2-(methoxycarbonyl)-threo-pentitol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,5-Anhydro-2,3-dideoxy-2-(methoxycarbonyl)-threo-pentitol is a tetrahydropyran derivative that is used in the preparation of pharmaceutical goods for the prevention or delay progression of Alzheimer disease, malaria and HIV infections.

Technology Process of 1,5-Anhydro-2,3-dideoxy-2-(methoxycarbonyl)-threopentitol

There total 20 articles about 1,5-Anhydro-2,3-dideoxy-2-(methoxycarbonyl)-threopentitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C7H10O4 → methyl cis-5-hydroxytetrahydropyran-3-carboxylate (1048962-91-9,1048962-94-2)

Guidance literature:

With 10 wt% Pd(OH)2 on carbon; hydrogen; In methanol; at 30 ℃; for 8h; under 7600.51 Torr; Temperature; Pressure;

Reference yield: 63.4%

methyl 5-oxotetrahydro-2H-pyran-3-carboxylate (127956-19-8) → (±)-cis-methyl 5-hydroxytetrahydro-2H-pyran-3-carboxylate (1048962-91-9,1048962-94-2)

Guidance literature:

With methanol; sodium tetrahydroborate; at 0 ℃; for 3h;

Reference yield: 40.7%

(±)-trans-methyl 5-((4-nitrobenzoyl)oxy)tetrahydro-2H-pyran-3-carboxylate → (±)-trans-methyl 5-hydroxytetrahydro-2H-pyran-3-carboxylate (1048962-91-9,1048962-94-2)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 2h;

upstream raw materials:

diazomethane

methyl 5-oxotetrahydro-2H-pyran-3-carboxylate

2H-pyran-3,5(4H,6H)-dione

methyl 4-oxotetrahydrofuran-3-carboxylate

Refernces

• 1、 -. "TRIAZOLE CARBOXYLIC ACIDS AS LPA ANTAGONISTS". . . Retrieved 2021/01/22.
• 2、 -. "Heterocyclic-substituted alkanamides as therapeutic compounds". . . Retrieved 2008/12/07.