3,5-difluoro-4-(4-(4-fluorophenyl)piperidin-1-yl)aniline

Base Information

Chemical Name:3,5-difluoro-4-(4-(4-fluorophenyl)piperidin-1-yl)aniline
CAS No.:1332356-31-6
Molecular Formula:C₁₇H₁₇F₃N₂
Molecular Weight:306.331
Hs Code.:
Mol file:1332356-31-6.mol

Synonyms:

Suppliers and Price of 3,5-difluoro-4-(4-(4-fluorophenyl)piperidin-1-yl)aniline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3,5-Difluoro-4-[4-(4-fluorophenyl)piperidin-1-yl]aniline
1mg
$ 165.00

Total 29 raw suppliers

Chemical Property of 3,5-difluoro-4-(4-(4-fluorophenyl)piperidin-1-yl)aniline

Chemical Property:

Boiling Point:436.9±45.0 °C(Predicted)
PKA:6.04±0.40(Predicted)
Density:1.272±0.06 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

3,5-Difluoro-4-[4-(4-fluorophenyl)piperidin-1-yl]aniline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 3,5-Difluoro-4-[4-(4-fluorophenyl)piperidin-1-yl]aniline is an antiviral agent and Pibrentasvir (1353900-92-1) intermediate.

Technology Process of 3,5-difluoro-4-(4-(4-fluorophenyl)piperidin-1-yl)aniline

There total 6 articles about 3,5-difluoro-4-(4-(4-fluorophenyl)piperidin-1-yl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1-(2,6-difluoro-4-nitrophenyl)-4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine

: 1332356-31-6
3,5-difluoro-4-(4-(4-fluorophenyl)piperidin-1-yl)aniline

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; under 760.051 Torr;
DOI:10.1021/acs.jmedchem.8b00082

Reference yield:

: 1332356-41-8
C₁₃H₁₄F₂N₂O₄

: 1332356-31-6
3,5-difluoro-4-(4-(4-fluorophenyl)piperidin-1-yl)aniline

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / water; acetone / 16 h / 50 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C

2.2: 1 h / -78 - 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; lithium chloride / water; 1,2-dimethoxyethane / 24 h / 100 °C / Inert atmosphere; Sealed tube

4.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 760.05 Torr

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sodium carbonate; lithium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; 1,2-dimethoxyethane; water; acetone; 3.1: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.8b00082

Reference yield:

: 177-11-7
4,4-ethylenedioxy-piperidine

: 1332356-31-6
3,5-difluoro-4-(4-(4-fluorophenyl)piperidin-1-yl)aniline

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / dimethyl sulfoxide / 4 h / 100 °C

2.1: hydrogenchloride / water; acetone / 16 h / 50 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C

3.2: 1 h / -78 - 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; lithium chloride / water; 1,2-dimethoxyethane / 24 h / 100 °C / Inert atmosphere; Sealed tube

5.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 760.05 Torr

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sodium carbonate; potassium carbonate; lithium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; 1,2-dimethoxyethane; water; dimethyl sulfoxide; acetone; 4.1: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.8b00082