4-Piperidinone, 1-(2,6-difluoro-4-nitrophenyl)-

Base Information

• Chemical Name: 4-Piperidinone, 1-(2,6-difluoro-4-nitrophenyl)-
• CAS No.: 565459-90-7
• Molecular Formula: C11H10F2N2O3
• Molecular Weight: 256.209

Synonyms:1-(2,6-Difluoro-4-nitrophenyl)-piperidin-4-one;1-(2,6-difluoro-4-nitro-phenyl)-piperidin-4-one;1-(2,6-difluoro-4-nitrophenyl)piperidin-4-one;1-(2,6-difluoro-4-nitrophenyl)-4-piperidinone;

Chemical Property of 4-Piperidinone, 1-(2,6-difluoro-4-nitrophenyl)-

Chemical Property:

• Boiling Point: 405.1±45.0 °C(Predicted)
• PSA: 66.13000
• Density: 1.435±0.06 g/cm3(Predicted)
• LogP: 2.63050

Purity/Quality:

99%, ^*data from raw suppliers

1-(2,6-Difluoro-4-nitrophenyl)piperidin-4-one 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Piperidinone, 1-(2,6-difluoro-4-nitrophenyl)-

There total 6 articles about 4-Piperidinone, 1-(2,6-difluoro-4-nitrophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3,4,5-trifluoronitrobenzene (66684-58-0) + 4-piperidone hydrochloride (41979-39-9) → 1-(2,6-difluoro-4-nitrophenyl)piperidin-4-one (565459-90-7)

Guidance literature:

4-piperidone hydrochloride; With triethylamine; In chloroform; for 0.5h;

3,4,5-trifluoronitrobenzene; In chloroform; at 65 - 70 ℃; for 8h;

Reference yield: 93.0%

→ 1-(2,6-difluoro-4-nitrophenyl)piperidin-4-one (565459-90-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield: 45.0%

piperidin-4-one (41661-47-6) + 3,4,5-trifluoronitrobenzene (66684-58-0) → 1-(2,6-difluoro-4-nitrophenyl)piperidin-4-one (565459-90-7)

Guidance literature:

With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 20 - 35 ℃; for 3h;

upstream raw materials:

piperidin-4-one

3,4,5-trifluoronitrobenzene

4-piperidone hydrochloride

C₁₃H₁₄F₂N₂O₄

Downstream raw materials:

C₁₃H₁₄F₂N₂O₄

3,5-difluoro-4-(4-(4-fluorophenyl)piperidin-1-yl)aniline

(S)-6,6'-((2R,5R)-1-(3,5-difluoro-4-(4-(4-fluorophenyl)piperidin-1-yl)phenyl)pyrrolidine-2,5-diyl)bis(5-fluoro-2-((S)pyrrolidin-2-yl)-1hbenzo[d]imidazole)

(2S,2'S)-di-tert-butyl 2,2'-(6,6'-((2R,5R)-1-(3,5-difluoro-4-(4-(4-fluorophenyl)piperidin-1-yl)phenyl)pyrrolidine-2,5-diyl)bis(5-fluoro-1H-benzo[d]imidazole-6,2-diyl))bis(pyrrolidine-1-carboxylate)

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