{2-[3-(4-carbamoyl-phenyl)-imidazo[1,2-b]pyridazin-6-ylamino]-ethyl}-methyl-carbamic acid tert-butyl ester

Base Information

Chemical Name:{2-[3-(4-carbamoyl-phenyl)-imidazo[1,2-b]pyridazin-6-ylamino]-ethyl}-methyl-carbamic acid tert-butyl ester
CAS No.:1454808-95-7
Molecular Formula:C₂₁H₂₆N₆O₃
Molecular Weight:410.476
Hs Code.:

Synonyms:

Suppliers and Price of {2-[3-(4-carbamoyl-phenyl)-imidazo[1,2-b]pyridazin-6-ylamino]-ethyl}-methyl-carbamic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
LP922761
5mg
$ 340.00

Tocris
LP922761 ≥98%(HPLC)
50
$ 819.00

Tocris
LP922761 ≥98%(HPLC)
10
$ 195.00

Total 2 raw suppliers

Chemical Property of {2-[3-(4-carbamoyl-phenyl)-imidazo[1,2-b]pyridazin-6-ylamino]-ethyl}-methyl-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

LP922761 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses LP 922761 is a potent AAK1 inhibitor (IC50 values are 4.8 and 7.6 nM in enzyme and cell assays, respectively). Exhibits some selectivity for AAK1 over BIKE, and exhibits no significant activity at opioid, adrenergic α2 or GABAA receptors. Orally bioavailable. Peripherally restricted.

Technology Process of {2-[3-(4-carbamoyl-phenyl)-imidazo[1,2-b]pyridazin-6-ylamino]-ethyl}-methyl-carbamic acid tert-butyl ester

There total 3 articles about {2-[3-(4-carbamoyl-phenyl)-imidazo[1,2-b]pyridazin-6-ylamino]-ethyl}-methyl-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [2-(3-bromo-imidazo[1,2-b]pyridazin-6-ylamino)-ethyl]-methyl-carbamic acid tert-butyl ester

: 123088-59-5
4-carbamoylphenylboronic acid

: 1454808-95-7
{2-[3-(4-carbamoyl-phenyl)-imidazo[1,2-b]pyridazin-6-ylamino]-ethyl}-methyl-carbamic acid tert-butyl ester

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate monohydrate; In 1,2-dimethoxyethane; dichloromethane; water; at 85 ℃; for 17h; Inert atmosphere;
DOI:10.1124/jpet.116.235333

Reference yield:

: 113501-27-2
6-fluoro-imidazo[1,2-b]pyridazine

: 1454808-95-7
{2-[3-(4-carbamoyl-phenyl)-imidazo[1,2-b]pyridazin-6-ylamino]-ethyl}-methyl-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; bromine / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 96 h / Reflux; Inert atmosphere

3: potassium phosphate monohydrate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dichloromethane; water; 1,2-dimethoxyethane / 17 h / 85 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate monohydrate; bromine; acetic acid; N-ethyl-N,N-diisopropylamine; In 1,2-dimethoxyethane; dichloromethane; water; isopropyl alcohol;
DOI:10.1124/jpet.116.235333

Reference yield:

: 1454808-95-7
{2-[3-(4-carbamoyl-phenyl)-imidazo[1,2-b]pyridazin-6-ylamino]-ethyl}-methyl-carbamic acid tert-butyl ester

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate monohydrate; In 1,2-dimethoxyethane; water; for 17h; Reflux; Inert atmosphere;