6-Fluoroimidazo[1,2-b]pyridazine

Base Information

Chemical Name:6-Fluoroimidazo[1,2-b]pyridazine
CAS No.:113501-27-2
Molecular Formula:C₆H₄FN₃
Molecular Weight:137.116
Hs Code.:2933998090
DSSTox Substance ID:DTXSID80569009
Wikidata:Q82455702
Mol file:113501-27-2.mol

Synonyms:6-Fluoroimidazo[1,2-b]pyridazine;113501-27-2;6-Fluoro-imidazo[1,2-b]pyridazine;MFCD11044764;Imidazo[1,2-b]pyridazine, 6-fluoro-;SCHEMBL9125832;DTXSID80569009;URQYCXJSMFGDRO-UHFFFAOYSA-N;CS-B1266;6-Fluoroimidazo[1,2-b]-pyridazine;AKOS006309963;CS-15025;SY354611;2,2,3,3,5,6-HEXACHLOROBIPHENYL

Suppliers and Price of 6-Fluoroimidazo[1,2-b]pyridazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-Fluoro-imidazo[1,2-b]pyridazine
100mg
$ 175.00

SynQuest Laboratories
6-Fluoroimidazo[1,2-b]-pyridazine 98%
1 g
$ 554.00

Crysdot
6-Fluoroimidazo[1,2-b]pyridazine 95+%
1g
$ 455.00

Chemenu
6-fluoroimidazo[1,2-b]pyridazine 95+%
1g
$ 892.00

Chemenu
6-fluoroimidazo[1,2-b]pyridazine 95+%
100mg
$ 232.00

Chemenu
6-fluoroimidazo[1,2-b]pyridazine 95+%
250mg
$ 357.00

Apolloscientific
6-Fluoroimidazo[1,2-b]-pyridazine >98%
1g
$ 346.00

American Custom Chemicals Corporation
6-FLUORO-IMIDAZO-[1,2-B]PYRIDAZINE 95.00%
5MG
$ 500.42

Alichem
6-Fluoroimidazo[1,2-b]pyridazine
1g
$ 899.94

Total 9 raw suppliers

Chemical Property of 6-Fluoroimidazo[1,2-b]pyridazine

Chemical Property:

PSA：30.19000
LogP:0.86840
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
XLogP3:0.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:137.03892530
Heavy Atom Count:10
Complexity:130

Purity/Quality:

97% ^*data from raw suppliers

6-Fluoro-imidazo[1,2-b]pyridazine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=NN2C1=NC=C2)F

Technology Process of 6-Fluoroimidazo[1,2-b]pyridazine

There total 2 articles about 6-Fluoroimidazo[1,2-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 6775-78-6
6-chloroimidazo[1,2-b]pyridazine

: 113501-27-2
6-fluoro-imidazo[1,2-b]pyridazine

Guidance literature:: With tetramethylammonium fluoride; In dimethyl sulfoxide; at 80 ℃; for 24h; Inert atmosphere; Sealed tube;
DOI:10.1021/acs.orglett.1c01490

Reference yield:

: 107-20-0
2-chloroethanal

: 108784-42-5
6-fluoro-pyridazin-3-yl amine

: 113501-27-2
6-fluoro-imidazo[1,2-b]pyridazine

Guidance literature:: In water; butan-1-ol; for 1h; Reflux;

Reference yield:

: 113501-27-2
6-fluoro-imidazo[1,2-b]pyridazine

: 1454808-95-7
{2-[3-(4-carbamoyl-phenyl)-imidazo[1,2-b]pyridazin-6-ylamino]-ethyl}-methyl-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; bromine / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 96 h / Reflux; Inert atmosphere

3: potassium phosphate monohydrate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dichloromethane; water; 1,2-dimethoxyethane / 17 h / 85 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate monohydrate; bromine; acetic acid; N-ethyl-N,N-diisopropylamine; In 1,2-dimethoxyethane; dichloromethane; water; isopropyl alcohol;
DOI:10.1124/jpet.116.235333