7-chloro-3-methyl-4-[methyl-(tetrahydro-pyran-4-ylmethyl)-carbamoyl]-pyrrolo[2,3-c]pyridine-1-carboxylic acid dimethyl-ethyl ester

Base Information

• Chemical Name: 7-chloro-3-methyl-4-[methyl-(tetrahydro-pyran-4-ylmethyl)-carbamoyl]-pyrrolo[2,3-c]pyridine-1-carboxylic acid dimethyl-ethyl ester
• CAS No.: 871870-12-1
• Molecular Formula: C₂₁H₂₈ClN₃O₄
• Molecular Weight: 421.924
• Mol file: 871870-12-1.mol

Synonyms:

Chemical Property of 7-chloro-3-methyl-4-[methyl-(tetrahydro-pyran-4-ylmethyl)-carbamoyl]-pyrrolo[2,3-c]pyridine-1-carboxylic acid dimethyl-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-chloro-3-methyl-4-[methyl-(tetrahydro-pyran-4-ylmethyl)-carbamoyl]-pyrrolo[2,3-c]pyridine-1-carboxylic acid dimethyl-ethyl ester

There total 8 articles about 7-chloro-3-methyl-4-[methyl-(tetrahydro-pyran-4-ylmethyl)-carbamoyl]-pyrrolo[2,3-c]pyridine-1-carboxylic acid dimethyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-methyl-N-(tetrahydro-pyran-4-ylmethyl) amine hydrochloride + 7-chloro-3-methyl-pyrrolo[2,3-c]pyridine-1,4-dicarboxylic acid 1-tert-butyl ester (871819-23-7) → 7-chloro-3-methyl-4-[methyl-(tetrahydro-pyran-4-ylmethyl)-carbamoyl]-pyrrolo[2,3-c]pyridine-1-carboxylic acid dimethyl-ethyl ester (871870-12-1)

Guidance literature:

With N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

7-chloro-4-iodo-3-methyl-1H-pyrrolo[2,3-c]pyridine (871819-21-5) → 7-chloro-3-methyl-4-[methyl-(tetrahydro-pyran-4-ylmethyl)-carbamoyl]-pyrrolo[2,3-c]pyridine-1-carboxylic acid dimethyl-ethyl ester (871870-12-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 2 h / 0 - 20 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 0.08 h / -40 - 20 °C / Molecular sieve 4A

2.3: pH 1

3.1: N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

With N-ethylmorpholine;; isopropylmagnesium chloride; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

7-chloro-4-iodo-3-methyl-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester (871819-22-6) → 7-chloro-3-methyl-4-[methyl-(tetrahydro-pyran-4-ylmethyl)-carbamoyl]-pyrrolo[2,3-c]pyridine-1-carboxylic acid dimethyl-ethyl ester (871870-12-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.08 h / -40 - 20 °C / Molecular sieve 4A

1.3: pH 1

2.1: N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

With N-ethylmorpholine;; isopropylmagnesium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

7-chloro-3-methyl-pyrrolo[2,3-c]pyridine-1,4-dicarboxylic acid 1-tert-butyl ester

7-chloro-4-iodo-3-methyl-1H-pyrrolo[2,3-c]pyridine

7-chloro-4-iodo-3-methyl-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester

3-nitropyridone