4-(3-(1-naphthoyl)-2-methyl-1H-indol-1-yl)butanoic acid

Base Information

• Chemical Name: 4-(3-(1-naphthoyl)-2-methyl-1H-indol-1-yl)butanoic acid
• CAS No.: 1427325-06-1
• Molecular Formula: C₂₄H₂₁NO₃
• Molecular Weight: 371.436
• Mol file: 1427325-06-1.mol

Synonyms:

Chemical Property of 4-(3-(1-naphthoyl)-2-methyl-1H-indol-1-yl)butanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-(1-naphthoyl)-2-methyl-1H-indol-1-yl)butanoic acid

There total 8 articles about 4-(3-(1-naphthoyl)-2-methyl-1H-indol-1-yl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

ethyl 4-(3-(1-naphthoyl)-2-methyl-1H-indol-1-yl) butanoate (1427325-10-7) → 4-(3-(1-naphthoyl)-2-methyl-1H-indol-1-yl)butanoic acid (1427325-06-1)

Guidance literature:

With potassium hydroxide; In water; ethyl acetate;

Reference yield:

(2-methyl-1H-indol-3-yl)(naphthalen-1-yl) methanone (80749-33-3) → 4-(3-(1-naphthoyl)-2-methyl-1H-indol-1-yl)butanoic acid (1427325-06-1)

Guidance literature:

Multi-step reaction with 2 steps

1: mineral oil; ethyl acetate; hexane

2: potassium hydroxide / water; ethyl acetate

With potassium hydroxide; In hexane; water; ethyl acetate; mineral oil;

Reference yield:

2-methyl-1H-indole (95-20-5) → 4-(3-(1-naphthoyl)-2-methyl-1H-indol-1-yl)butanoic acid (1427325-06-1)

Guidance literature:

Multi-step reaction with 3 steps

1: thiophen-2-yl magnesium bromide; ammonium chloride / thionyl chloride; diethyl ether

2: mineral oil; ethyl acetate; hexane

3: potassium hydroxide / water; ethyl acetate

With potassium hydroxide; ammonium chloride; thiophen-2-yl magnesium bromide; In thionyl chloride; diethyl ether; hexane; water; ethyl acetate; mineral oil;

upstream raw materials:

(2-methyl-1H-indol-3-yl)(naphthalen-1-yl) methanone

ethyl 4-(3-(1-naphthoyl)-2-methyl-1H-indol-1-yl) butanoate

2-methyl-1H-indole

1-naphthalenecarboxylic acid

Refernces

• 1、 -. "Detection of synthetic cannabinoids". . . Retrieved 2014/03/22.